Regulation of prostate cancer by hormone-responsive G protein-coupled receptors

• Published in: Pharmacology & therapeutics (Oxford) Vol. 191; pp. 135 - 147
• Main Authors: Wang, Wei, Chen, Zhao-Xia, Guo, Dong-Yu, Tao, Ya-Xiong
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2018
• Subjects: Androgen receptor; Castration resistance; G protein-coupled receptors; Prostate cancer; Reproduction; G protein-coupled receptors; PLC; LDL-A; cAMP; CYP17A1; ADT; DHT; Reproduction; GHS; c-JNK; LHR; FSH; GnRH; PSA; GHSR; PKA; Castration resistance; PKC; DAG; MAPK; IP3; GnRHR; AR; ERK1/2; FSHR; RXFP; Androgen receptor; GPCR; BPH; LH; Prostate cancer; CRPC; HPG

Regulation of prostate cancer by androgen and androgen receptor (AR), and blockade of AR signaling by AR antagonists and steroidogenic enzyme inhibitors have been extensively studied. G protein-coupled receptors (GPCRs) are a family of membrane receptors that regulate almost all physiological proces...