The effects of antiepileptic drugs on bone health: A systematic review

• Published in: Epilepsy research Vol. 173; p. 106619
• Main Authors: Griepp, Daniel W., Kim, David J., Ganz, Marc, Dolphin, Eugene J., Sotudeh, Nadia, Burekhovich, Steven A., Naziri, Qais
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2021
• Subjects: Anticonvulsants - adverse effects; Antiepileptic; Bone Density; Bone mineral density; Carbamazepine - adverse effects; Epilepsy; Epilepsy - drug therapy; Humans; Lamotrigine - pharmacology; Lamotrigine - therapeutic use; Long-term therapy; Osteopenia; Osteoporosis; NEIAEDs; VPA; Epilepsy; LS; FN; AEDs; TPM; CLZ; Osteoporosis; GBP; EIAEDs; BMD; CBZ; PHT; ESM; Osteopenia; MP; Antiepileptic; VGB; PB; DEXA; Long-term therapy; Bone mineral density; OXC; LEV; LTG

•There is little compelling evidence supporting that enzyme-inducers are more harmful to bone than non-enzyme inducers.•Biochemical serum markers of bone turnover do not reliably correlate with changes in bone density.•Bone loss is less likely to be observed during initial years of antiepileptic dru...