Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019

• Published in: The Journal of infectious diseases Vol. 223; no. 11; pp. 1842 - 1854
• Main Authors: Ramos da Silva, Suzane, Ju, Enguo, Meng, Wen, Paniz Mondolfi, Alberto E, Dacic, Sanja, Green, Anthony, Bryce, Clare, Grimes, Zachary, Fowkes, Mary, Sordillo, Emilia M, Cordon-Cardo, Carlos, Guo, Haitao, Gao, Shou-Jiang
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2021
• Subjects: ACE2; Alveoli; Angiotensin; Angiotensin-converting enzyme 2; Autopsy; Cell activation; Coronaviruses; COVID-19; Cytotoxicity; Endothelial cells; Helper cells; Immunoregulation; Inflammation; Interleukin 6; Leukocytes (neutrophilic); Lymphocytes; Lymphocytes B; Lymphocytes T; Macrophages; Monocytes; Natural killer cells; Neutrophils; Parenchyma; Peptidyl-dipeptidase A; Severe acute respiratory syndrome coronavirus 2; Thromboembolism; Tropism; Viral infections; COVID-19; thromboemboli; SARS-CoV-2; diffuse alveolar damage; inflammation; immunofluorescence assay; immunosuppression; immunohistochemistry; IL-6; cell tropism

Abstract Background Coronavirus disease 2019 (COVID-19) patients manifest with pulmonary symptoms reflected by diffuse alveolar damage (DAD), excessive inflammation, and thromboembolism. The mechanisms mediating these processes remain unclear. Methods We performed multicolor staining for severe acut...