Effect of β-Blocker Cessation on Chronotropic Incompetence and Exercise Tolerance in Patients With Advanced Heart Failure

• Published in: Circulation. Heart failure Vol. 5; no. 5; pp. 560 - 565
• Main Authors: Hirsh, Benjamin J., Mignatti, Andrea, Garan, A. Reshad, Uriel, Nir, Colombo, Paolo, Sims, Daniel B., Jorde, Ulrich P.
• Format: Journal Article
• Language: English
• Published: United States 01.09.2012
• Subjects: Adrenergic beta-Antagonists - administration & dosage; Adult; Analysis of Variance; Biomarkers - blood; Bisoprolol - administration & dosage; Carbazoles - administration & dosage; Drug Administration Schedule; Exercise Test; Exercise Tolerance - drug effects; Female; Heart Failure - blood; Heart Failure - diagnosis; Heart Failure - drug therapy; Heart Failure - physiopathology; Heart Rate - drug effects; Humans; Male; Metoprolol - administration & dosage; Middle Aged; New York City; Norepinephrine - blood; Oxygen Consumption - drug effects; Propanolamines - administration & dosage; Prospective Studies; Respiration - drug effects; Time Factors; New York City

Chronotropic incompetence is defined as the inability to reach 80% of heart rate (HR) reserve or 80% of the maximally predicted HR during exercise. The presence of chronotropic incompetence is associated with reduced peak oxygen consumption, and rate-responsive pacing therapy is under investigation...