Spontaneous Loss of Tolerance of Autoreactive B Cells in Act1 -Deficient Rheumatoid Factor Transgenic Mice

• Published in: The Journal of immunology (1950) Vol. 191; no. 5; pp. 2155 - 2163
• Main Authors: Giltiay, Natalia V, Lu, Yi, Cullen, Jaime L, Jørgensen, Trine N, Shlomchik, Mark J, Li, Xiaoxia
• Format: Journal Article
• Language: English
• Published: United States 01.09.2013
• Subjects: Adaptor Proteins, Signal Transducing - deficiency; Adaptor Proteins, Signal Transducing - immunology; Animals; Antibody Formation; Autoantibodies - biosynthesis; Autoantibodies - immunology; Autoimmunity - immunology; B-Cell Activating Factor - immunology; B-Lymphocytes - immunology; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Mice; Mice, Inbred BALB C; Mice, Transgenic; Rheumatoid Factor - genetics; Rheumatoid Factor - immunology; Self Tolerance - immunology

Self-reactive B cells in BALB/c AM14 transgenic (Tg) rheumatoid factor mice are not subject to central or peripheral tolerization. Instead, they remain at a stage of “clonal ignorance”; that is, they do not proliferate and differentiate into Ab-forming cells. However, the immunoregulatory mechanisms...