A dynamical system for the IGF1-AKT signaling pathway in skeletal muscle adaptation

• Published in: BioSystems Vol. 202; p. 104355
• Main Authors: Villota-Narvaez, Yesid, Garzon-Alvarado, Diego A., Ramirez-Martinez, Angelica M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2021
• Subjects: Biochemical modeling; Biomechanics; Cellular signaling pathways; Dynamical systems; Mechanobiology; Muscle adaptation; Population dynamics; Biomechanics; Biochemical modeling; Cellular signaling pathways; Muscle adaptation; Mechanobiology; Population dynamics; Dynamical systems

Physical activity produces a change in skeletal-muscle size by activating synthesis or degradation of protein, which are outcomes of stimulating the IGF1-AKT signaling pathway. In this work, we propose a mathematical model that predicts the variation in muscle size under different activity condition...