Robustness in crossover regulation during meiosis

Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting...

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Published inNature cell biology Vol. 14; no. 4; pp. 335 - 337
Main Author Kotwaliwale, Chitra V.
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LanguageEnglish
Published London Nature Publishing Group UK 01.04.2012
Nature Publishing Group
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Abstract Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting insights into how recombination is fine-tuned to enforce a robust meiotic program.
AbstractList Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting insights into how recombination is fine-tuned to enforce a robust meiotic program.
Author Kotwaliwale, Chitra V.
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10.1016/j.cub.2004.11.038
10.1016/j.cell.2006.05.044
10.1038/268460a0
10.1042/BST0340523
10.1073/pnas.0402724101
10.1038/nrg761
10.1016/j.devcel.2008.07.006
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10.1073/pnas.0600418103
10.1126/science.1086605
10.1007/s10577-007-1150-1
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SubjectTerms 631/80/641/1633
631/80/641/2002
Animals
Biomedical and Life Sciences
Birth defects
Cancer Research
Cell Biology
Chromosomes
Developmental Biology
Homeostasis
Life Sciences
Male
Meiosis - genetics
news-and-views
Recombination, Genetic - genetics
Stem Cells
Title Robustness in crossover regulation during meiosis
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