Robustness in crossover regulation during meiosis
Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting...
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Published in | Nature cell biology Vol. 14; no. 4; pp. 335 - 337 |
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Format | Journal Article |
Language | English |
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Nature Publishing Group UK
01.04.2012
Nature Publishing Group |
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Abstract | Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting insights into how recombination is fine-tuned to enforce a robust meiotic program. |
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AbstractList | Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting insights into how recombination is fine-tuned to enforce a robust meiotic program. |
Author | Kotwaliwale, Chitra V. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22469828$$D View this record in MEDLINE/PubMed |
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SubjectTerms | 631/80/641/1633 631/80/641/2002 Animals Biomedical and Life Sciences Birth defects Cancer Research Cell Biology Chromosomes Developmental Biology Homeostasis Life Sciences Male Meiosis - genetics news-and-views Recombination, Genetic - genetics Stem Cells |
Title | Robustness in crossover regulation during meiosis |
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