Robustness in crossover regulation during meiosis

Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting...

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Bibliographic Details
Published inNature cell biology Vol. 14; no. 4; pp. 335 - 337
Main Author Kotwaliwale, Chitra V.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2012
Nature Publishing Group
Subjects
631/80/641/1633
631/80/641/2002
Animals
Biomedical and Life Sciences
Birth defects
Cancer Research
Cell Biology
Chromosomes
Developmental Biology
Homeostasis
Life Sciences
Male
Meiosis - genetics
news-and-views
Recombination, Genetic - genetics
Stem Cells
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Summary:Meiotic recombination produces physical linkages between homologous chromosomes that enable their segregation to opposite poles during meiosis I. In the absence of recombination, chromosomes mis-segregate, resulting in aneuploidy associated with severe birth defects. A recent study provides exciting insights into how recombination is fine-tuned to enforce a robust meiotic program.
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ISSN:1465-7392
1476-4679
DOI:10.1038/ncb2474