Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma

• Published in: The European respiratory journal Vol. 43; no. 6; pp. 1661 - 1668
• Main Authors: MARTINEZ-GARCIA, Miguel-Angel, MARTORELL-CALATAYUD, Antonio, CAMPOS-RODRIGUEZ, Francisco, FARRE, Ramón, NAGORE, Eduardo, VALERO, Irene, SELMA, Maria Jose, CHINER, Eusebi, LANDETE, Pedro, MONTSERRAT, Josep-Maria, CARRERA, Cristina, PEREZ-GIL, Amalia
• Format: Journal Article
• Language: English
• Published: Leeds Maney 01.06.2014
• Subjects: Adult; Aged; Biological and medical sciences; Continuous Positive Airway Pressure - methods; Dermatology; Female; Humans; Male; Medical sciences; Melanocytes - pathology; Melanoma - complications; Melanoma - diagnosis; Melanoma, Cutaneous Malignant; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Multivariate Analysis; Neoplasm Metastasis; Oxygen - chemistry; Percutaneous Coronary Intervention - methods; Pneumology; Polysomnography; Respiratory system : syndromes and miscellaneous diseases; Skin Neoplasms - complications; Skin Neoplasms - diagnosis; Sleep; Sleep Apnea Syndromes - complications; Treatment Outcome; Tumors; Tumors of the skin and soft tissue. Premalignant lesions; Nervous system diseases; Sleep apnea syndrome; Association; Respiratory disease; Malignant melanoma; Biological marker; Skin; Malignant tumor; Cancer; Aggressiveness
• DOI: 10.1183/09031936.00115413
• ISSN: 0903-1936

Some recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality and incidence but no study has focused on a specific type of cancer. The objective of this study was to analyse the relationship between the severity of SDB and factors related to cutaneous malignant melanoma (CMM) aggressiveness. We performed a multicentre observational study in 82 consecutive patients diagnosed with CMM. 56 patients in whom melanoma measurements were available were finally included in the study. Melanoma measurements of aggressiveness included: tumour mitotic rate, Breslow index, presence of ulceration, stage of disease and growth rate of melanoma. A sleep study was performed in all the included patients. Multivariate analyses were used to examine the independent relationship between SDB severity (apnoea-hypopnea index (AHI) and nocturnal oxygen desaturation indexes (ODI3% and ODI4%)) and measures of CMM aggressiveness. 60.7% of patients had SDB (AHI ≥ 5) and 14.3% severe obstructive sleep apnoea (AHI ≥ 30). In fully adjusted multivariate analyses, AHI (OR 1.08, 95% CI 1.02-1.14), ODI3% (OR 1.08, 95% CI 1.02-1.11) and ODI4% (OR 1.1, 95% CI 1.02-1.2) were independently associated with an increased melanoma growth rate. Furthermore, AHI, ODI4% and ODI3% were significantly correlated with other aggressiveness factors of CMM, such as Breslow index, presence of ulceration and mitotic index. SDB severity markers are associated with some aggressiveness markers of CMM.