Hsp27 (HspB1) and αB-crystallin (HspB5) as therapeutic targets

• Published in: FEBS letters Vol. 581; no. 19; pp. 3665 - 3674
• Main Authors: Arrigo, André-Patrick, Simon, Stéphanie, Gibert, Benjamin, Kretz-Remy, Carole, Nivon, Mathieu, Czekalla, Anna, Guillet, Dominique, Moulin, Maryline, Diaz-Latoud, Chantal, Vicart, Patrick
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 31.07.2007
• Subjects: Cancers; Hsp27; Myopathies; Neurodegenerative diseases; αB-crystallin; Myopathies; Neurodegenerative diseases; Hsp27; αB-crystallin; Cancers

Hsp27 and αB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative-inflammation conditions...