Hsp27 (HspB1) and αB-crystallin (HspB5) as therapeutic targets

Hsp27 and αB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative-inflammation conditions...

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Published inFEBS letters Vol. 581; no. 19; pp. 3665 - 3674
Main Authors Arrigo, André-Patrick, Simon, Stéphanie, Gibert, Benjamin, Kretz-Remy, Carole, Nivon, Mathieu, Czekalla, Anna, Guillet, Dominique, Moulin, Maryline, Diaz-Latoud, Chantal, Vicart, Patrick
Format Journal Article
LanguageEnglish
Published Elsevier B.V 31.07.2007
Subjects
Cancers
Hsp27
Myopathies
Neurodegenerative diseases
αB-crystallin
Myopathies
Neurodegenerative diseases
Hsp27
αB-crystallin
Cancers
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Abstract Hsp27 and αB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative-inflammation conditions. In addition, these proteins share anti-apoptotic properties and are tumorigenic when expressed in cancer cells. This review summarizes the current knowledge about Hsp27 and αB-crystallin and the implications, either positive or deleterious, of these proteins in pathologies such as neurodegenerative diseases, myopathies, asthma, cataracts and cancers. Approaches towards therapeutic strategies aimed at modulating the expression and/or the activities of Hsp27 and αB-crystallin are presented.
AbstractList Hsp27 and αB‐crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative‐inflammation conditions. In addition, these proteins share anti‐apoptotic properties and are tumorigenic when expressed in cancer cells. This review summarizes the current knowledge about Hsp27 and αB‐crystallin and the implications, either positive or deleterious, of these proteins in pathologies such as neurodegenerative diseases, myopathies, asthma, cataracts and cancers. Approaches towards therapeutic strategies aimed at modulating the expression and/or the activities of Hsp27 and αB‐crystallin are presented.
Author Kretz-Remy, Carole
Moulin, Maryline
Arrigo, André-Patrick
Diaz-Latoud, Chantal
Gibert, Benjamin
Simon, Stéphanie
Vicart, Patrick
Nivon, Mathieu
Czekalla, Anna
Guillet, Dominique
Author_xml – sequence: 1
  givenname: André-Patrick
  surname: Arrigo
  fullname: Arrigo, André-Patrick
  email: arrigo@univ-lyon1.fr
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 2
  givenname: Stéphanie
  surname: Simon
  fullname: Simon, Stéphanie
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 3
  givenname: Benjamin
  surname: Gibert
  fullname: Gibert, Benjamin
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 4
  givenname: Carole
  surname: Kretz-Remy
  fullname: Kretz-Remy, Carole
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 5
  givenname: Mathieu
  surname: Nivon
  fullname: Nivon, Mathieu
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 6
  givenname: Anna
  surname: Czekalla
  fullname: Czekalla, Anna
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 7
  givenname: Dominique
  surname: Guillet
  fullname: Guillet, Dominique
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 8
  givenname: Maryline
  surname: Moulin
  fullname: Moulin, Maryline
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 9
  givenname: Chantal
  surname: Diaz-Latoud
  fullname: Diaz-Latoud, Chantal
  organization: Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France
– sequence: 10
  givenname: Patrick
  surname: Vicart
  fullname: Vicart, Patrick
  organization: EA 300 Stress et Pathologies du Cytosquelette, UFR de Biochimie, Université Paris 7, Paris, France
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ContentType Journal Article
Copyright 2007 Federation of European Biochemical Societies
FEBS Letters 581 (2007) 1873-3468 © 2015 Federation of European Biochemical Societies
Copyright_xml – notice: 2007 Federation of European Biochemical Societies
– notice: FEBS Letters 581 (2007) 1873-3468 © 2015 Federation of European Biochemical Societies
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Keywords Myopathies
Neurodegenerative diseases
Hsp27
αB-crystallin
Cancers
Language English
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Snippet Hsp27 and αB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These...
Hsp27 and αB‐crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These...
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wiley
elsevier
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StartPage 3665
SubjectTerms Cancers
Hsp27
Myopathies
Neurodegenerative diseases
αB-crystallin
Title Hsp27 (HspB1) and αB-crystallin (HspB5) as therapeutic targets
URI https://dx.doi.org/10.1016/j.febslet.2007.04.033
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.febslet.2007.04.033
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