HNF-1α-SNARE connection

• Published in: Diabetes, obesity & metabolism Vol. 9; no. s2; pp. 40 - 45
• Main Authors: Yamagata, K, Nammo, T, Sato, Y, Saisho, K, Shoda, H, Fukui, K
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.11.2007; Blackwell Publishing Ltd
• Subjects: collectrin; exocytosis; HNF-1α; maturity-onset diabetes of the young; noninsulin-dependent diabetes mellitus; snapin

Maturity-onset diabetes of the young (MODY) is a monogenic form of type 2 diabetes mellitus that is characterized by impairment of glucose-stimulated insulin secretion from pancreatic β-cells. We previously reported that heterozygous mutations of the hepatocyte nuclear factor (HNF)-1α gene cause a f...