Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation

• Published in: Cancer discovery Vol. 10; no. 5; pp. 664 - 673
• Main Authors: Jiang, Peiyong, Sun, Kun, Peng, Wenlei, Cheng, Suk Hang, Ni, Meng, Yeung, Philip C., Heung, Macy M.S., Xie, Tingting, Shang, Huimin, Zhou, Ze, Chan, Rebecca W.Y., Wong, John, Wong, Vincent W.S., Poon, Liona C., Leung, Tak Yeung, Lam, W.K. Jacky, Chan, Jason Y.K., Chan, Henry L.Y., Chan, K.C. Allen, Chiu, Rossa W.K., Lo, Y.M. Dennis
• Format: Journal Article
• Language: English
• Published: United States 01.05.2020

Plasma DNA fragmentomics is an emerging area of research covering plasma DNA sizes, end points, and nucleosome footprints. In the present study, we found a significant increase in the diversity of plasma DNA end motifs in patients with hepatocellular carcinoma (HCC). Compared with patients without H...