GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

• Published in: Endocrinology (Philadelphia) Vol. 155; no. 4; pp. 1280 - 1290
• Main Authors: Pyke, Charles, Heller, R. Scott, Kirk, Rikke K, Ørskov, Cathrine, Reedtz-Runge, Steffen, Kaastrup, Peter, Hvelplund, Anders, Bardram, Linda, Calatayud, Dan, Knudsen, Lotte Bjerre
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.04.2014
• Subjects: Animals; Antibodies, Monoclonal - chemistry; Blood Pressure; Body Weight; Cell Line; Cricetinae; Duodenum - metabolism; Exenatide; Glucagon - metabolism; Glucagon-Like Peptide 1 - analogs & derivatives; Glucagon-Like Peptide 1 - chemistry; Glucagon-Like Peptide-1 Receptor; Haplorhini; Heart Rate; Humans; Insulin - metabolism; Insulin Secretion; Ligands; Liraglutide; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptides - chemistry; Protein Binding; Receptors, Glucagon - metabolism; Tissue Distribution; Transfection; Venoms - chemistry

Glucagon-like peptide 1 (GLP-1) analogs are increasingly being used in the treatment of type 2 diabetes. It is clear that these drugs lower blood glucose through an increase in insulin secretion and a lowering of glucagon secretion; in addition, they lower body weight and systolic blood pressure and...