nm23-H1 is a negative regulator of TGF-β1-dependent induction of epithelial–mesenchymal transition

• Published in: Experimental cell research Vol. 319; no. 5; pp. 740 - 749
• Main Authors: Zhao, Rongzhi, Gong, Lei, Li, Lin, Guo, Lili, Zhu, Daxing, Wu, Zhihao, Zhou, Qinghua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.03.2013
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; beta Catenin - genetics; beta Catenin - metabolism; Blotting, Western; Cadherins - genetics; Cadherins - metabolism; Cell Movement; Cell Proliferation; embryogenesis; Epithelial-Mesenchymal Transition; fibronectins; Flow Cytometry; Fluorescent Antibody Technique; Humans; Luciferases - metabolism; Lung cancer metastasis; lung neoplasms; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; metastasis; Metastasis suppressor; migratory behavior; neoplasm cells; NM23 Nucleoside Diphosphate Kinases - genetics; NM23 Nucleoside Diphosphate Kinases - metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Src kinase; transcription factors; transforming growth factor beta 1; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-β; Tumor Cells, Cultured; tumor suppressor genes; Wound Healing; Lung cancer metastasis; Epithelial–mesenchymal transition; Src kinase; Metastasis suppressor; Transforming growth factor-β

Members of transforming growth factor-β(TGF-β) family are the main inducers of epithelial–mesenchymal transition (EMT) during embryogenesis and cancer pathogenesis. However, a significant crosstalk between TGF-β and other signals occurs during the induction of EMT. nm23-H1 was the first metastasis s...