Palladium-catalyzed selective defluorinative sulfenylation for the synthesis of fluorovinylthioethers

An efficient transformation of trifluoromethylated compounds to monofluoroalkenes was developed through Pd-catalyzed selective defluorinative sulfenylation. A variety of alpha-fluorovinylthioethers were prepared in good yields from alpha-trifluoromethylated benzyl bromides and odorless disulfides.

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Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 7; no. 20; pp. 3174 - 3178
Main Authors He, Shi-Yu, Zhang, Xing-Guo
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.10.2020
Royal Society of Chemistry
Subjects
Bromides
Chemistry
Chemistry, Organic
Organic chemistry
Palladium
Physical Sciences
Science & Technology
FUNCTIONALIZATION
TRIFLUOROTOLUENES
FLUOROALKENES
LEWIS-ACID
GEM-DIFLUOROALKENES
FLUORINE
CLEAVAGE
F BOND ACTIVATION
HYDRODEFLUORINATION
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Summary:An efficient transformation of trifluoromethylated compounds to monofluoroalkenes was developed through Pd-catalyzed selective defluorinative sulfenylation. A variety of alpha-fluorovinylthioethers were prepared in good yields from alpha-trifluoromethylated benzyl bromides and odorless disulfides.
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d0qo00818d