In vitro characterization of taurine transport using the human brain microvascular endothelial cell line as a human blood-brain barrier model

• Published in: Drug metabolism and pharmacokinetics Vol. 61; p. 101040
• Main Authors: Tega, Yuma, Kawauchi, Yusuke, Akanuma, Shin-ichi, Inagaki, Mai, Tachikawa, Masanori, Hosoya, Ken-ichi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2025
• Subjects: Biological Transport - physiology; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain - blood supply; Brain - metabolism; Cell Line; Endothelial Cells - metabolism; hCMEC/D3 cell line; Humans; Membrane Glycoproteins; Membrane Transport Proteins - metabolism; Microvessels - metabolism; Monocarboxylate transporter 7; Monocarboxylic Acid Transporters - genetics; Monocarboxylic Acid Transporters - metabolism; Taurine; Taurine - metabolism; Taurine transporter; Taurine; hCMEC/D3 cell line; Monocarboxylate transporter 7; Blood-brain barrier; Taurine transporter

Taurine, a sulfur-containing β-amino acid, has various roles in the brain including cellular osmoregulation and neuroprotection. For adequate supply to the brain, taurine has to pass through the blood-brain barrier (BBB); however, the associated mechanism behind crossing the human BBB is not fully u...