Immune Response to Anti-Lymphocyte Globulin

Summary The appearance of antibodies to rabbit IgG in rats injected with the IgG fraction of rabbit anti-lymphocyte serum was examined. While 13 of 24 animals injected with ALG developed significant anti-rabbit IgG titers, only 2 rats of 18 injected with comparable amounts of normal rabbit IgG devel...

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Published inThe Journal of immunology (1950) Vol. 100; no. 3; pp. 654 - 658
Main Authors Jasin, Hugo E, Lourie, Seth H, Currey, H. L. F, Ziff, Morris
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.03.1968
Subjects
Animals
Antibody Formation
Arthritis - immunology
Cattle
Erythrocytes - immunology
Freund's Adjuvant
Hemagglutination Tests
Immune Sera
Immunoglobulin G
Lymphocytes - immunology
Rabbits
Rats
Sheep
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Abstract Summary The appearance of antibodies to rabbit IgG in rats injected with the IgG fraction of rabbit anti-lymphocyte serum was examined. While 13 of 24 animals injected with ALG developed significant anti-rabbit IgG titers, only 2 rats of 18 injected with comparable amounts of normal rabbit IgG developed antibody, and in these it was present in relatively low titer. Evidence of immunosuppression was observed in the ALG treated animals in a reduction of antibody formation to sheep erythrocytes and a suppression of Freund's adjuvant-induced arthritis. In a group of animals simultaneously injected with bovine γ-globulin, the immune response to this protein was similar in both the experimental and control groups. The enhancement phenomenon observed, therefore, appeared to be specific for IgG with anti-lymphocyte activity.
AbstractList Summary The appearance of antibodies to rabbit IgG in rats injected with the IgG fraction of rabbit anti-lymphocyte serum was examined. While 13 of 24 animals injected with ALG developed significant anti-rabbit IgG titers, only 2 rats of 18 injected with comparable amounts of normal rabbit IgG developed antibody, and in these it was present in relatively low titer. Evidence of immunosuppression was observed in the ALG treated animals in a reduction of antibody formation to sheep erythrocytes and a suppression of Freund's adjuvant-induced arthritis. In a group of animals simultaneously injected with bovine γ-globulin, the immune response to this protein was similar in both the experimental and control groups. The enhancement phenomenon observed, therefore, appeared to be specific for IgG with anti-lymphocyte activity.
Author Jasin, Hugo E
Currey, H. L. F
Ziff, Morris
Lourie, Seth H
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Snippet Summary The appearance of antibodies to rabbit IgG in rats injected with the IgG fraction of rabbit anti-lymphocyte serum was examined. While 13 of 24 animals...
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StartPage 654
SubjectTerms Animals
Antibody Formation
Arthritis - immunology
Cattle
Erythrocytes - immunology
Freund's Adjuvant
Hemagglutination Tests
Immune Sera
Immunoglobulin G
Lymphocytes - immunology
Rabbits
Rats
Sheep
Title Immune Response to Anti-Lymphocyte Globulin
URI http://www.jimmunol.org/cgi/content/abstract/100/3/654
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