Rapid tranquillisation in a psychiatric emergency hospital in Lebanon: TREC-Lebanon – a pragmatic randomised controlled trial of intramuscular haloperidol and promethazine v. intramuscular haloperidol, promethazine and chlorpromazine

• Published in: Psychological medicine Vol. 52; no. 13; pp. 2751 - 2759
• Main Authors: Dib, Joseph E., Yaacoub, Hiba Edward, Ikdais, Werner Henry, Atallah, Elie, Merheb, Tony Jean, Ajaltouni, Jean, Akkari, Myriam, Mourad, Marc, Nasr, Maria Elias, Hachem, Dory, Kazour, Francois, Tahan, Fouad, Haddad, Georges, Azar, Jocelyn, Zoghbi, Marouan, Haddad, Chadia, Hallit, Souheil, Adams, Clive E.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2022
• Subjects: Aggressive behavior; Aggressiveness; Antipsychotic Agents - therapeutic use; Chlorpromazine; Chlorpromazine - therapeutic use; Clinical trials; Consent; Drug dosages; Haloperidol; Haloperidol - adverse effects; Hospitals, Psychiatric; Humans; Intervention; Lebanon; Mental disorders; Original Article; Patient safety; Patients; Promethazine; Promethazine - therapeutic use; Psychomotor Agitation; Recurrence; Risk factors; Sedation; Side effects; Uncertainty; Lebanon; United Kingdom > UK; Beirut Lebanon; intramuscular; lebanon; Rapid tranquillisation; TREC; randomised clinical trial

Agitated patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians differ in opinion and practice. In Lebanon, the use of the triple therapy haloperidol plus promethazine plus chlorpromazine (HPC) is frequently used but no studies in...