Targeting IL-8 and Its Receptors in Prostate Cancer: Inflammation, Stress Response, and Treatment Resistance

• Published in: Cancers Vol. 16; no. 16; p. 2797
• Main Authors: McClelland, Shauna, Maxwell, Pamela J, Branco, Cristina, Barry, Simon T, Eberlein, Cath, LaBonte, Melissa J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.08.2024; MDPI
• Subjects: Androgen receptors; Androgens; Angiogenesis; Artificial chromosomes; B cells; Biology; Biomarkers; Cancer therapies; Castration; Cell growth; Cell migration; Cell proliferation; Cell survival; Chemokine receptors; Chemokines; Clinical trials; CXCR2 protein; Cytokines; Development and progression; Drug resistance; Endothelial cells; Extracellular matrix; Health aspects; Homeopathy; Hypoxia; Immune system; Immunosuppressive agents; Inflammation; Interleukin 8; Interleukins; Kinases; Materia medica and therapeutics; Metastases; Metastasis; Neutrophils; Patients; Phosphatase; Prostate cancer; Proteins; Radiation; Review; Signal transduction; Therapeutic targets; Therapeutics; Tumor microenvironment; Tumors; hypoxia; PTEN; chemokines; interleukin-8 (IL-8); inhibitory combinations; PI3K/AKT pathway; prostate cancer; androgen receptor; CXCR1; immune response; inflammation; CXCR2; clinical trials; cytokines; tumour microenvironment; drug resistance; monoclonal antibodies; small-molecule inhibitors

This review delves into the intricate roles of interleukin-8 (IL-8) and its receptors, CXCR1 and CXCR2, in prostate cancer (PCa), particularly in castration-resistant (CRPC) and metastatic CRPC (mCRPC). This review emphasizes the crucial role of the tumour microenvironment (TME) and inflammatory cyt...