TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier

• Published in: Journal of cell science Vol. 124; no. Pt 10; pp. 1681 - 1690
• Main Authors: Jackson, Ben, Brown, Stuart J, Avilion, Ariel A, O'Shaughnessy, Ryan F L, Sully, Katherine, Akinduro, Olufolake, Murphy, Mark, Cleary, Michael L, Byrne, Carolyn
• Format: Journal Article
• Language: English
• Published: England Company of Biologists 15.05.2011
• Subjects: Animals; Base Sequence; Cell Differentiation - genetics; Cell Differentiation - physiology; Cornified Envelope Proline-Rich Proteins - genetics; Drosophila; Epidermal Cells; Epidermis - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Keratinocytes - metabolism; Mice; Mice, Transgenic; Promoter Regions, Genetic; Repressor Proteins - genetics; Repressor Proteins - metabolism; Skin - cytology; Skin - metabolism; Skin Physiological Phenomena - genetics

The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is str...