TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier
The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is str...
Saved in:
Published in | Journal of cell science Vol. 124; no. Pt 10; pp. 1681 - 1690 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Company of Biologists
15.05.2011
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is strong evidence for body-site-dependent dermal programming of epidermal differentiation in which the epidermis responds by altering expression of key barrier proteins, but the underlying mechanisms have not been defined. The LCE multigene cluster encodes barrier proteins that are differentially expressed over the body surface, and perturbation of LCE cluster expression is linked to the common regional skin disease psoriasis. LCE subclusters comprise genes expressed variably in either external barrier-forming epithelia (e.g. skin) or in internal epithelia with less stringent barriers (e.g. tongue). We demonstrate here that a complex of TALE homeobox transcription factors PBX1, PBX2 and Pknox (homologues of Drosophila Extradenticle and Homothorax) preferentially regulate external rather than internal LCE gene expression, competitively binding with SP1 and SP3. Perturbation of TALE protein expression in stratified squamous epithelia in mice produces external but not internal barrier abnormalities. We conclude that epidermal barrier genes, such as the LCE multigene cluster, are regulated by TALE homeodomain transcription factors to produce regional epidermal barriers. |
---|---|
AbstractList | The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is strong evidence for body-site-dependent dermal programming of epidermal differentiation in which the epidermis responds by altering expression of key barrier proteins, but the underlying mechanisms have not been defined. The
LCE
multigene cluster encodes barrier proteins that are differentially expressed over the body surface, and perturbation of
LCE
cluster expression is linked to the common regional skin disease psoriasis.
LCE
subclusters comprise genes expressed variably in either external barrier-forming epithelia (e.g. skin) or in internal epithelia with less stringent barriers (e.g. tongue). We demonstrate here that a complex of TALE homeobox transcription factors PBX1, PBX2 and Pknox (homologues of
Drosophila
Extradenticle and Homothorax) preferentially regulate external rather than internal
LCE
gene expression, competitively binding with SP1 and SP3. Perturbation of TALE protein expression in stratified squamous epithelia in mice produces external but not internal barrier abnormalities. We conclude that epidermal barrier genes, such as the
LCE
multigene cluster, are regulated by TALE homeodomain transcription factors to produce regional epidermal barriers. The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is strong evidence for body-site-dependent dermal programming of epidermal differentiation in which the epidermis responds by altering expression of key barrier proteins, but the underlying mechanisms have not been defined. The LCE multigene cluster encodes barrier proteins that are differentially expressed over the body surface, and perturbation of LCE cluster expression is linked to the common regional skin disease psoriasis. LCE subclusters comprise genes expressed variably in either external barrier-forming epithelia (e.g. skin) or in internal epithelia with less stringent barriers (e.g. tongue). We demonstrate here that a complex of TALE homeobox transcription factors PBX1, PBX2 and Pknox (homologues of Drosophila Extradenticle and Homothorax) preferentially regulate external rather than internal LCE gene expression, competitively binding with SP1 and SP3. Perturbation of TALE protein expression in stratified squamous epithelia in mice produces external but not internal barrier abnormalities. We conclude that epidermal barrier genes, such as the LCE multigene cluster, are regulated by TALE homeodomain transcription factors to produce regional epidermal barriers. |
Author | Byrne, Carolyn Brown, Stuart J Avilion, Ariel A Sully, Katherine Akinduro, Olufolake Jackson, Ben Murphy, Mark O'Shaughnessy, Ryan F L Cleary, Michael L |
AuthorAffiliation | 2 Department of Pathology, Stanford University School of Medicine , Stanford, CA 94305 , USA 1 Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London E1 2AT , UK |
AuthorAffiliation_xml | – name: 1 Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London E1 2AT , UK – name: 2 Department of Pathology, Stanford University School of Medicine , Stanford, CA 94305 , USA |
Author_xml | – sequence: 1 givenname: Ben surname: Jackson fullname: Jackson, Ben organization: Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK – sequence: 2 givenname: Stuart J surname: Brown fullname: Brown, Stuart J – sequence: 3 givenname: Ariel A surname: Avilion fullname: Avilion, Ariel A – sequence: 4 givenname: Ryan F L surname: O'Shaughnessy fullname: O'Shaughnessy, Ryan F L – sequence: 5 givenname: Katherine surname: Sully fullname: Sully, Katherine – sequence: 6 givenname: Olufolake surname: Akinduro fullname: Akinduro, Olufolake – sequence: 7 givenname: Mark surname: Murphy fullname: Murphy, Mark – sequence: 8 givenname: Michael L surname: Cleary fullname: Cleary, Michael L – sequence: 9 givenname: Carolyn surname: Byrne fullname: Byrne, Carolyn |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21511732$$D View this record in MEDLINE/PubMed |
BookMark | eNqF0U2LFDEQBuAgK-7s6sUfILkJYq-ppPN1EZZh_IABL-s5pNPVsxm6kzbpEfz39jLroidPdaiHlyreK3KRckJCXgO7Ad7yD8dQb5jWUvJnZAOt1o0FoS_IhjEOjZVCXJKrWo-MMc2tfkEuOUgALfiGHO9u9zt6nyfMfZ58THQuecGYKi14OI1-QVrjgk2dMcQhBrpgmWLyI-3jMGDBtES_xJze0_12Rw-YsFKfeopz7Fe6ws6XErG8JM8HP1Z89TivyfdPu7vtl2b_7fPX7e2-CUKLpQm284F3YK1SPkjRmcCADaFXYKQ1XW_YSlTwg-2ha720imkmQXlpsOUgrsnHc-586ibsw3ph8aObS5x8-eWyj-7fTYr37pB_OgFGtPYh4O1jQMk_TlgXN8UacBx9wnyqzioDCjRn_5VGtdpILdUq351lKLnWgsPTPcDcQ4tubdGdW1zxm78_eKJ_ahO_AQAZm-Q |
CitedBy_id | crossref_primary_10_1111_j_1600_0625_2012_01472_x crossref_primary_10_1111_exd_14515 crossref_primary_10_1111_bjd_14284 crossref_primary_10_3390_cells9122628 crossref_primary_10_1074_jbc_M117_802900 crossref_primary_10_1242_dev_068973 crossref_primary_10_1016_j_ijpharm_2012_06_005 crossref_primary_10_1172_JCI72718 crossref_primary_10_5021_ad_2014_26_3_421 crossref_primary_10_3389_fcell_2020_00054 |
Cites_doi | 10.1111/1523-1747.ep12532899 10.1128/MCB.20.4.1436-1447.2000 10.1016/S1097-2765(04)00260-6 10.1073/pnas.96.15.8551 10.1074/jbc.M505262200 10.1038/sj.onc.1208372 10.1387/ijdb.15272373 10.1167/iovs.08-3327 10.1242/dev.125.8.1541 10.1038/jid.2008.413 10.1038/ng.310 10.1371/journal.pgen.1000041 10.1006/viro.1996.0530 10.1016/j.cell.2008.12.043 10.1016/S0925-4773(00)00540-2 10.1038/jid.2010.36 10.1074/jbc.M100336200 10.1002/dvdy.10290 10.1074/jbc.272.2.1308 10.1002/(SICI)1097-0134(19980701)32:1<1::AID-PROT1>3.0.CO;2-Q 10.1111/1523-1747.ep12343405 10.1038/ng.313 10.1242/dev.128.18.3543 10.1007/s11882-008-0048-0 10.1101/gad.1610508 10.1074/jbc.271.38.23154 10.1046/j.1523-1747.1998.00092.x 10.1111/j.0022-202X.2005.23699.x 10.1124/mol.62.1.154 10.1046/j.1523-1747.2000.00955.x 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I 10.1016/j.ydbio.2004.08.030 10.1387/ijdb.072304al 10.1074/jbc.271.1.512 10.1042/bj3480045 10.1101/pdb.prot5279 10.1093/bioinformatics/bti473 10.1128/MCB.24.12.5324-5331.2004 10.1016/j.ydbio.2005.10.032 10.1016/j.cell.2008.05.024 10.1038/sj.jid.5700792 10.1093/nar/30.9.2043 10.1007/s00403-005-0623-3 10.1073/pnas.231489198 10.1097/ACI.0b013e32832e7d36 10.1093/nar/25.15.3110 10.1083/jcb.200105009 10.1016/S0928-0987(03)00176-3 10.1007/978-1-60761-380-0_19 10.1016/j.stem.2008.03.004 10.1006/geno.1997.4952 |
ContentType | Journal Article |
Copyright | 2011. 2011 |
Copyright_xml | – notice: 2011. 2011 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 8FD FR3 P64 RC3 5PM |
DOI | 10.1242/jcs.077552 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Genetics Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts |
DatabaseTitleList | MEDLINE CrossRef Genetics Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1477-9137 |
EndPage | 1690 |
ExternalDocumentID | 10_1242_jcs_077552 21511732 |
Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: Cancer Research UK grantid: C5314/A6695 – fundername: NCI NIH HHS grantid: R01 CA090735 – fundername: NCI NIH HHS grantid: CA90735 |
GroupedDBID | --- -DZ -~X 0R~ 18M 2WC 34G 39C 3O- 4.4 4R4 53G 5GY 5RE 5VS 85S ABDNZ ABPPZ ABTAH ACGFO ACGFS ACIWK ACNCT ACPRK ADBBV ADCOW AEILP AENEX AFFNX AFRAH AGGIJ ALMA_UNASSIGNED_HOLDINGS BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF F5P F9R GX1 H13 HZ~ IH2 INIJC KQ8 NPM O9- OK1 P2P R.V RCB RHF RHI RNS SJN TN5 TR2 UPT W2D W8F WH7 WOQ YQT ZY4 ~02 ~KM AAYXX CITATION 7X8 8FD FR3 P64 RC3 5PM |
ID | FETCH-LOGICAL-c373t-c9bac2b19966ac53b8c010fcd618598bd80c9b6caf9d1b4a596070516a58e4213 |
ISSN | 0021-9533 |
IngestDate | Tue Sep 17 21:04:11 EDT 2024 Fri Oct 25 09:42:52 EDT 2024 Fri Oct 25 10:29:19 EDT 2024 Fri Dec 06 03:23:35 EST 2024 Wed Oct 16 00:48:00 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | Pt 10 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c373t-c9bac2b19966ac53b8c010fcd618598bd80c9b6caf9d1b4a596070516a58e4213 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: EpiStem Ltd, 48 Grafton Street, Manchester M13 9XX, UK Present address: Geron Corporation, Menlo Park, CA 94025, USA These authors contributed equally to this work Present address: Immunbiology and Dermatology, Institute of Child Health, UCL, London WC1N 1EH, UK **Present address: Actelion Pharmaceuticals Ltd, Gewerbestr. 16, CH-4123 Allschwil, Switzerland |
PMID | 21511732 |
PQID | 864785756 |
PQPubID | 23479 |
PageCount | 10 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3183491 proquest_miscellaneous_968161720 proquest_miscellaneous_864785756 crossref_primary_10_1242_jcs_077552 pubmed_primary_21511732 |
PublicationCentury | 2000 |
PublicationDate | 2011-05-15 |
PublicationDateYYYYMMDD | 2011-05-15 |
PublicationDate_xml | – month: 05 year: 2011 text: 2011-05-15 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Journal of cell science |
PublicationTitleAlternate | J Cell Sci |
PublicationYear | 2011 |
Publisher | Company of Biologists |
Publisher_xml | – name: Company of Biologists |
References | Cartharius (2021042521310604700_R10) 2005; 21 Ezhkova (2021042521310604700_R17) 2009; 136 Laurent (2021042521310604700_R30) 2008; 52 Cabral (2021042521310604700_R8) 2001; 276 Vasioukhin (2021042521310604700_R48) 1999; 96 Byrne (2021042521310604700_R7) 2010; 585 Elias (2021042521310604700_R16) 2009; 9 Jave-Suarez (2021042521310604700_R25) 2006; 297 Marjukka Suhonen (2021042521310604700_R35) 2003; 20 Moens (2021042521310604700_R38) 2006; 291 Marshall (2021042521310604700_R37) 2001; 98 Liu (2021042521310604700_R31) 2008; 4 Brown (2021042521310604700_R5) 2009; 129 Komuves (2021042521310604700_R27) 2000; 218 Stelnicki (2021042521310604700_R46) 1998; 110 Wong (2021042521310604700_R49) 2005; 24 Fognani (2021042521310604700_R19) 2002; 30 Gregory (2021042521310604700_R20) 2002; 62 Mack (2021042521310604700_R33) 2005; 280 Murphy (2021042521310604700_R39) 2010; 51 Hardman (2021042521310604700_R23) 1998; 125 Elias (2021042521310604700_R15) 2008; 8 Manley (2021042521310604700_R34) 2004; 276 Apt (2021042521310604700_R1) 1996; 224 Lopez-Bayghen (2021042521310604700_R32) 1996; 271 Zhang (2021042521310604700_R50) 2009; 41 Komuves (2021042521310604700_R28) 2003; 227 de Cid (2021042521310604700_R12) 2009; 41 Marshall (2021042521310604700_R36) 2000; 114 Zhao (2021042521310604700_R51) 1997; 45 Dhouailly (2021042521310604700_R13) 2004; 48 Prowse (2021042521310604700_R42) 1997; 272 Carey (2021042521310604700_R9) 2009; 2009 Brown (2021042521310604700_R6) 2007; 127 Kennett (2021042521310604700_R26) 1997; 25 Selleri (2021042521310604700_R45) 2004; 24 Berkes (2021042521310604700_R4) 2004; 14 LaPres (2021042521310604700_R29) 1996; 271 Olivera-Martinez (2021042521310604700_R40) 2001; 100 Hanley (2021042521310604700_R22) 1996; 106 Ficara (2021042521310604700_R18) 2008; 2 Rinn (2021042521310604700_R43) 2008; 22 Baden (2021042521310604700_R2) 1983; 80 Chidgey (2021042521310604700_R11) 2001; 155 Jackson (2021042521310604700_R24) 2005; 124 Berger (2021042521310604700_R3) 2008; 133 Gudjonsson (2021042521310604700_R21) 2010; 130 Phillips (2021042521310604700_R41) 2000; 1 Dickson (2021042521310604700_R14) 2000; 20 Subramaniam (2021042521310604700_R47) 1998; 32 Selleri (2021042521310604700_R44) 2001; 128 |
References_xml | – volume: 80 start-page: 124 year: 1983 ident: 2021042521310604700_R2 article-title: The growth and differentiation of cultural newborn rat keratinocytes publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12532899 contributor: fullname: Baden – volume: 20 start-page: 1436 year: 2000 ident: 2021042521310604700_R14 article-title: Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.4.1436-1447.2000 contributor: fullname: Dickson – volume: 14 start-page: 465 year: 2004 ident: 2021042521310604700_R4 article-title: Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential publication-title: Mol. Cell doi: 10.1016/S1097-2765(04)00260-6 contributor: fullname: Berkes – volume: 96 start-page: 8551 year: 1999 ident: 2021042521310604700_R48 article-title: The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.96.15.8551 contributor: fullname: Vasioukhin – volume: 280 start-page: 29904 year: 2005 ident: 2021042521310604700_R33 article-title: Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model publication-title: J. Biol. Chem. doi: 10.1074/jbc.M505262200 contributor: fullname: Mack – volume: 24 start-page: 3525 year: 2005 ident: 2021042521310604700_R49 article-title: E2F suppression and Sp1 overexpression are sufficient to induce the differentiation-specific marker, transglutaminase type 1, in a squamous cell carcinoma cell line publication-title: Oncogene doi: 10.1038/sj.onc.1208372 contributor: fullname: Wong – volume: 48 start-page: 85 year: 2004 ident: 2021042521310604700_R13 article-title: Skin field formation: morphogenetic events publication-title: Int. J. Dev. Biol. doi: 10.1387/ijdb.15272373 contributor: fullname: Dhouailly – volume: 51 start-page: 795 year: 2010 ident: 2021042521310604700_R39 article-title: Essential role for Pbx1 in corneal morphogenesis publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-3327 contributor: fullname: Murphy – volume: 125 start-page: 1541 year: 1998 ident: 2021042521310604700_R23 article-title: Patterned acquisition of skin barrier function during development publication-title: Development doi: 10.1242/dev.125.8.1541 contributor: fullname: Hardman – volume: 129 start-page: 543 year: 2009 ident: 2021042521310604700_R5 article-title: Eczema genetics: current state of knowledge and future goals publication-title: J. Invest. Dermatol. doi: 10.1038/jid.2008.413 contributor: fullname: Brown – volume: 41 start-page: 205 year: 2009 ident: 2021042521310604700_R50 article-title: Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21 publication-title: Nat. Genet. doi: 10.1038/ng.310 contributor: fullname: Zhang – volume: 4 start-page: e1000041 year: 2008 ident: 2021042521310604700_R31 article-title: A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000041 contributor: fullname: Liu – volume: 224 start-page: 281 year: 1996 ident: 2021042521310604700_R1 article-title: High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter publication-title: Virology doi: 10.1006/viro.1996.0530 contributor: fullname: Apt – volume: 136 start-page: 1122 year: 2009 ident: 2021042521310604700_R17 article-title: Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells publication-title: Cell doi: 10.1016/j.cell.2008.12.043 contributor: fullname: Ezhkova – volume: 100 start-page: 233 year: 2001 ident: 2021042521310604700_R40 article-title: Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1 publication-title: Mech. Dev. doi: 10.1016/S0925-4773(00)00540-2 contributor: fullname: Olivera-Martinez – volume: 130 start-page: 1829 year: 2010 ident: 2021042521310604700_R21 article-title: Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models publication-title: J. Invest. Dermatol. doi: 10.1038/jid.2010.36 contributor: fullname: Gudjonsson – volume: 276 start-page: 19231 year: 2001 ident: 2021042521310604700_R8 article-title: Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function publication-title: J. Biol. Chem. doi: 10.1074/jbc.M100336200 contributor: fullname: Cabral – volume: 227 start-page: 192 year: 2003 ident: 2021042521310604700_R28 article-title: HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development publication-title: Dev. Dyn. doi: 10.1002/dvdy.10290 contributor: fullname: Komuves – volume: 272 start-page: 1308 year: 1997 ident: 2021042521310604700_R42 article-title: Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.2.1308 contributor: fullname: Prowse – volume: 32 start-page: 1 year: 1998 ident: 2021042521310604700_R47 article-title: The biology workbench – a seamless database and analysis environment for the biologist publication-title: Proteins doi: 10.1002/(SICI)1097-0134(19980701)32:1<1::AID-PROT1>3.0.CO;2-Q contributor: fullname: Subramaniam – volume: 106 start-page: 404 year: 1996 ident: 2021042521310604700_R22 article-title: Epidermal barrier ontogenesis: maturation in serum-free media and acceleration by glucocorticoids and thyroid hormone but not selected growth factors publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12343405 contributor: fullname: Hanley – volume: 41 start-page: 211 year: 2009 ident: 2021042521310604700_R12 article-title: Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis publication-title: Nat. Genet. doi: 10.1038/ng.313 contributor: fullname: de Cid – volume: 128 start-page: 3543 year: 2001 ident: 2021042521310604700_R44 article-title: Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation publication-title: Development doi: 10.1242/dev.128.18.3543 contributor: fullname: Selleri – volume: 8 start-page: 299 year: 2008 ident: 2021042521310604700_R15 article-title: Skin barrier function publication-title: Curr. Allergy Asthma Rep. doi: 10.1007/s11882-008-0048-0 contributor: fullname: Elias – volume: 22 start-page: 303 year: 2008 ident: 2021042521310604700_R43 article-title: A dermal HOX transcriptional program regulates site-specific epidermal fate publication-title: Genes Dev. doi: 10.1101/gad.1610508 contributor: fullname: Rinn – volume: 271 start-page: 23154 year: 1996 ident: 2021042521310604700_R29 article-title: Identification of a functional determinant of differentiation-dependent expression in the involucrin gene publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.38.23154 contributor: fullname: LaPres – volume: 110 start-page: 110 year: 1998 ident: 2021042521310604700_R46 article-title: HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development publication-title: J. Invest. Dermatol. doi: 10.1046/j.1523-1747.1998.00092.x contributor: fullname: Stelnicki – volume: 124 start-page: 1062 year: 2005 ident: 2021042521310604700_R24 article-title: Late cornified envelope family in differentiating epithelia-response to calcium and ultraviolet irradiation publication-title: J. Invest. Dermatol. doi: 10.1111/j.0022-202X.2005.23699.x contributor: fullname: Jackson – volume: 62 start-page: 154 year: 2002 ident: 2021042521310604700_R20 article-title: The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1alpha-mediated activation of the UDP-glucuronosyltransferase 2B17 gene publication-title: Mol. Pharmacol. doi: 10.1124/mol.62.1.154 contributor: fullname: Gregory – volume: 114 start-page: 967 year: 2000 ident: 2021042521310604700_R36 article-title: SPRR1 gene induction and barrier formation occur as coordinated moving fronts in terminally differentiating epithelia publication-title: J. Invest. Dermatol. doi: 10.1046/j.1523-1747.2000.00955.x contributor: fullname: Marshall – volume: 218 start-page: 636 year: 2000 ident: 2021042521310604700_R27 article-title: Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation publication-title: Dev. Dyn. doi: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I contributor: fullname: Komuves – volume: 276 start-page: 301 year: 2004 ident: 2021042521310604700_R34 article-title: Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2004.08.030 contributor: fullname: Manley – volume: 52 start-page: 9 year: 2008 ident: 2021042521310604700_R30 article-title: PBX proteins: much more than Hox cofactors publication-title: Int. J. Dev. Biol. doi: 10.1387/ijdb.072304al contributor: fullname: Laurent – volume: 271 start-page: 512 year: 1996 ident: 2021042521310604700_R32 article-title: Transcriptional analysis of the 5′-noncoding region of the human involucrin gene publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.1.512 contributor: fullname: Lopez-Bayghen – volume: 1 start-page: 45 year: 2000 ident: 2021042521310604700_R41 article-title: Identification of an involucrin promoter transcriptional response element with activity restricted to keratinocytes publication-title: Biochem. J. doi: 10.1042/bj3480045 contributor: fullname: Phillips – volume: 2009 year: 2009 ident: 2021042521310604700_R9 article-title: Chromatin Immunoprecipitation (ChIP) publication-title: Cold Spring Harb. Protoc. doi: 10.1101/pdb.prot5279 contributor: fullname: Carey – volume: 21 start-page: 2933 year: 2005 ident: 2021042521310604700_R10 article-title: MatInspector and beyond: promoter analysis based on transcription factor binding sites publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti473 contributor: fullname: Cartharius – volume: 24 start-page: 5324 year: 2004 ident: 2021042521310604700_R45 article-title: The TALE homeodomain protein Pbx2 is not essential for development and long-term survival publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.12.5324-5331.2004 contributor: fullname: Selleri – volume: 291 start-page: 193 year: 2006 ident: 2021042521310604700_R38 article-title: Hox cofactors in vertebrate development publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2005.10.032 contributor: fullname: Moens – volume: 133 start-page: 1266 year: 2008 ident: 2021042521310604700_R3 article-title: Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences publication-title: Cell doi: 10.1016/j.cell.2008.05.024 contributor: fullname: Berger – volume: 127 start-page: 1782 year: 2007 ident: 2021042521310604700_R6 article-title: Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes publication-title: J. Invest. Dermatol. doi: 10.1038/sj.jid.5700792 contributor: fullname: Brown – volume: 30 start-page: 2043 year: 2002 ident: 2021042521310604700_R19 article-title: Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.9.2043 contributor: fullname: Fognani – volume: 297 start-page: 372 year: 2006 ident: 2021042521310604700_R25 article-title: The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors publication-title: Arch. Dermatol. Res. doi: 10.1007/s00403-005-0623-3 contributor: fullname: Jave-Suarez – volume: 98 start-page: 13031 year: 2001 ident: 2021042521310604700_R37 article-title: Differentially expressed late constituents of the epidermal cornified envelope publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.231489198 contributor: fullname: Marshall – volume: 9 start-page: 437 year: 2009 ident: 2021042521310604700_R16 article-title: Abnormal skin barrier in the etiopathogenesis of atopic dermatitis publication-title: Curr. Opin. Allergy Clin. Immunol. doi: 10.1097/ACI.0b013e32832e7d36 contributor: fullname: Elias – volume: 25 start-page: 3110 year: 1997 ident: 2021042521310604700_R26 article-title: Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription publication-title: Nucleic Acids Res. doi: 10.1093/nar/25.15.3110 contributor: fullname: Kennett – volume: 155 start-page: 821 year: 2001 ident: 2021042521310604700_R11 article-title: Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation publication-title: J. Cell Biol. doi: 10.1083/jcb.200105009 contributor: fullname: Chidgey – volume: 20 start-page: 107 year: 2003 ident: 2021042521310604700_R35 article-title: Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin publication-title: Eur. J. Pharm. Sci. doi: 10.1016/S0928-0987(03)00176-3 contributor: fullname: Marjukka Suhonen – volume: 585 start-page: 271 year: 2010 ident: 2021042521310604700_R7 article-title: Whole-mount assays for gene induction and barrier formation in the developing epidermis publication-title: Methods Mol. Biol. doi: 10.1007/978-1-60761-380-0_19 contributor: fullname: Byrne – volume: 2 start-page: 484 year: 2008 ident: 2021042521310604700_R18 article-title: Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.03.004 contributor: fullname: Ficara – volume: 45 start-page: 250 year: 1997 ident: 2021042521310604700_R51 article-title: Positional cloning of novel skin-specific genes from the human epidermal differentiation complex publication-title: Genomics doi: 10.1006/geno.1997.4952 contributor: fullname: Zhao |
SSID | ssj0007297 |
Score | 2.1126592 |
Snippet | The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 1681 |
SubjectTerms | Animals Base Sequence Cell Differentiation - genetics Cell Differentiation - physiology Cornified Envelope Proline-Rich Proteins - genetics Drosophila Epidermal Cells Epidermis - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Keratinocytes - metabolism Mice Mice, Transgenic Promoter Regions, Genetic Repressor Proteins - genetics Repressor Proteins - metabolism Skin - cytology Skin - metabolism Skin Physiological Phenomena - genetics |
Title | TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier |
URI | https://www.ncbi.nlm.nih.gov/pubmed/21511732 https://search.proquest.com/docview/864785756 https://search.proquest.com/docview/968161720 https://pubmed.ncbi.nlm.nih.gov/PMC3183491 |
Volume | 124 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb5swFLaiTpP2Mu2-7CZL2xuDQQADj1mUrqraaVJbKW_INmbJlJCqJZO6X7eftnOwMdC10tYXFAGJic_HudjnfIeQD4kIykIWIIEyi9woZanLwTC4KpG8gACCqRLXIY-_soOz6HARL0aj372spV0tPPnrxrqSu0gVzoFcsUr2PyRrfxROwGeQLxxBwnD8NxlPj-bOcrtREFtu-KrJtsLulbgV0LSYVw5uDrtYTokpQY5JfVnbvii1lkwTnc_m2E9ZadJmhZ1jQWmvHcEvsKvdLV4sLvw7xozabJyubv9zV2lmA_6TGhNJnUPPgu3nam0eYgpDAWbsJczFOVny3fclqmQNiCtQSfuec-T1VyxwCTZ2dc2mThwyuQzwjLrfJuC5vzDZJI3Emh7DU1otR7jRHGh6GKu3dfF1C1C_p4YDpvvAGJOOW4E3mgvwT9BcyEsPmQA1lW4PN-ebBjjoFQWJWYYdMHZ_O56hToyQPuEeUjFi94Yviy7JCEIX0zRY_ydDkAvjfupGbQip9RBD7-ivkOd65m7PFTp9RB4a6dOpBuRjMlLVE3Jfz_LVU_IDYUl7sKQtLGkLSzqAJW1hSa_B8iMFUNIGlBRASS0oqQHlM3K2Pz-dHbimpYcrwySsXZkJLicCU98Zl3EoUukHfikLBn5jlooi9eEWJnmZFYGIeAwBdgJ2g_E4VdEkCJ-TvWpbqZeEyigpYnC_y3QSRomCUKEQwgf3m08EK6N4TN63U5mfa-aWHCNemPsc5j7Xcz8mtJ3lHBQrvjS8UtvdZZ5iFTYEM-z2WzKAGUYA_pi80HKxI7UCHZNkIDF7A9K6D69Uq2VD724Q9erO33xNHnSv3RuyV1_s1FtwnWvxrkHnH-lbyG4 |
link.rule.ids | 230,314,780,784,885,27924,27925 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=TALE+homeodomain+proteins+regulate+site-specific+terminal+differentiation%2C+LCE+genes+and+epidermal+barrier&rft.jtitle=Journal+of+cell+science&rft.au=Jackson%2C+Ben&rft.au=Brown%2C+Stuart+J.&rft.au=Avilion%2C+Ariel+A.&rft.au=O%27Shaughnessy%2C+Ryan+F.+L.&rft.date=2011-05-15&rft.pub=Company+of+Biologists&rft.issn=0021-9533&rft.eissn=1477-9137&rft.volume=124&rft.issue=10&rft.spage=1681&rft.epage=1690&rft_id=info:doi/10.1242%2Fjcs.077552&rft_id=info%3Apmid%2F21511732&rft.externalDBID=PMC3183491 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9533&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9533&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9533&client=summon |