Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2

• Published in: Cytokine (Philadelphia, Pa.) Vol. 178; p. 156592
• Main Authors: Kawata, Daisuke, Iwai, Hideyuki, Oba, Seiya, Komiya, Yoji, Koike, Ryuji, Miyamoto, Sho, Kanno, Takayuki, Ainai, Akira, Suzuki, Tadaki, Hosoya, Tadashi, Yasuda, Shinsuke
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2024
• Subjects: Ataxia Telangiectasia Mutated Proteins; COVID-19; Humans; Inflammatory cytokine; Monocyte-derived macrophage; NF-κB; SARS-CoV-2; Spike Glycoprotein, Coronavirus - genetics; Spike protein (S-protein); Variants of concern (VOCs); Monocyte-derived macrophage; NF-κB; SARS-CoV-2; Variants of concern (VOCs); Inflammatory cytokine; Spike protein (S-protein)

SARS-CoV-2 spike proteins (S-proteins) possess pro-inflammatory abilities via the NF-κB pathway in human macrophages. The production of NF-κB-responsive cytokines by macrophages in response to S-proteins varies among SARS-CoV-2 strains. A similar trend of immunostimulatory abilities was observed bet...