Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans - Spencer, Andrew G; Labonte, Eric D; Rosenbaum, David P; Plato, Craig F; Carreras, Christopher W; Leadbetter, Michael R; Kozuka, Kenji; Kohler, Jill; Koo-McCoy, Samantha; He, Limin; Bell, Noah; Tabora, Jocelyn; et al. (Science translational medicine, 2014)
Keywords: Albuminuria - complications; Albuminuria - drug therapy; Albuminuria - physiopathology; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Animals; Blood Pressure - drug effects; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrolytes - urine; Enalapril - pharmacology; Enalapril - therapeutic use; Feces; Healthy Volunteers; Humans; Hypertrophy; Intestinal Mucosa - metabolism; Intestines - drug effects; Isoquinolines - administration & dosage; Isoquinolines - pharmacokinetics; Isoquinolines - pharmacology; Isoquinolines - therapeutic use; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Male; Myocardium - metabolism; Myocardium - pathology; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - physiopathology; Sodium - metabolism; Sodium Chloride, Dietary - administration & dosage; Sodium Chloride, Dietary - pharmacology; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers - antagonists & inhibitors; Sodium-Hydrogen Exchangers - metabolism; Sulfonamides - administration & dosage; Sulfonamides - pharmacokinetics; Sulfonamides - pharmacology; Sulfonamides - therapeutic use