Prostaglandin E2–Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti–PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection

• Published in: The Journal of immunology (1950) Vol. 203; no. 5; pp. 1313 - 1324
• Main Authors: Sajiki, Yamato, Konnai, Satoru, Okagawa, Tomohiro, Nishimori, Asami, Maekawa, Naoya, Goto, Shinya, Watari, Kei, Minato, Erina, Kobayashi, Atsushi, Kohara, Junko, Yamada, Shinji, Kaneko, Mika K, Kato, Yukinari, Takahashi, Hirofumi, Terasaki, Nobuhiro, Takeda, Akira, Yamamoto, Keiichi, Toda, Mikihiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: AAI 01.09.2019
• Subjects: Infectious Disease and Host Response

Bovine leukemia virus (BLV) infection is a chronic viral infection of cattle and endemic in many countries, including Japan. Our previous study demonstrated that PGE2, a product of cyclooxygenase (COX) 2, suppresses Th1 responses in cattle and contributes to the progression of Johne disease, a chron...