β-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression

• Published in: The Journal of biological chemistry Vol. 292; no. 43; pp. 17577 - 17586
• Main Authors: Li, Yaqiong, Zhang, Lianjun, Hu, Yuqiong, Chen, Min, Han, Feng, Qin, Yan, Cui, Xiuhong, Duo, Shuguang, Tang, Fuchou, Gao, Fei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.10.2017; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; beta Catenin - biosynthesis; beta Catenin - genetics; beta-catenin (B-catenin); cell differentiation; Cell Transdifferentiation; Ctnnb1; Developmental Biology; Female; Forkhead Box Protein L2; Forkhead Transcription Factors - biosynthesis; Forkhead Transcription Factors - genetics; foxl2; Gene Expression Regulation; Granulosa Cells - cytology; Granulosa Cells - metabolism; Granulosa-like cells; Male; Mice; Mice, Transgenic; Sertoli cells; Sertoli Cells - cytology; Sertoli Cells - metabolism; Sex-Determining Region Y Protein - genetics; Sex-Determining Region Y Protein - metabolism; Signal Transduction; somatic cell genetics; testis; transformation; cell differentiation; somatic cell genetics; foxl2; testis; Ctnnb1; beta-catenin (B-catenin); transformation; Sertoli cells; Granulosa-like cells

Sertoli and granulosa cells are two major types of somatic cells in male and female gonads, respectively. Previous studies have shown that Sertoli and granulosa cells are derived from common progenitor cells and that differentiation of these two cell types is regulated by sex differentiation genes....