Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis

• Published in: British journal of anaesthesia : BJA Vol. 125; no. 5; pp. 750 - 761
• Main Authors: Kamp, Jasper, Jonkman, Kelly, van Velzen, Monique, Aarts, Leon, Niesters, Marieke, Dahan, Albert, Olofsen, Erik
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2020
• Subjects: ketamine; modelling; NONMEM; population pharmacokinetics; racemic ketamine; S-ketamine; S-ketamine; ketamine; modelling; racemic ketamine; NONMEM; population pharmacokinetics

Recent studies show activity of ketamine metabolites, such as hydroxynorketamine, in producing rapid relief of depression-related symptoms and analgesia. To improve our understanding of the pharmacokinetics of ketamine and metabolites norketamine, dehydronorketamine, and hydroxynorketamine, we devel...