A red-fleshed apple rich in anthocyanins improves endothelial function, reduces inflammation, and modulates the immune system in hypercholesterolemic subjects: the AppleCOR study

• Published in: Food & function Vol. 15; no. 11; pp. 5825 - 5841
• Main Authors: Pedret, Anna, Companys, Judit, Calderón-Pérez, Lorena, Llauradó, Elisabet, Pla-Pagà, Laura, Salamanca, Patricia, Sandoval-Ramírez, Berner-Andree, Catalán, Úrsula, Fernández-Castillejo, Sara, Yuste, Silvia, Macià, Alba, Gutiérrez-Tordera, Laia, Bulló, Mónica, Camps, Jordi, Canela, Núria, Valls, Rosa Maria, Rubió-Piqué, Laura, Motilva, Maria José, Solà, Rosa
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 04.06.2024
• Subjects: Acute effects; Adult; Aged; Anthocyanins; Anthocyanins - administration & dosage; Anthocyanins - pharmacology; Apples; Biomarkers; C-Reactive Protein; Complement system; Consumption; Female; Fruit - chemistry; Fruits; Health risks; Humans; Hypercholesterolemia - drug therapy; Hyperemia; Immune system; Immune System - drug effects; Immunoglobulins; Inflammation; Ischemia; Lipids; Male; Malus - chemistry; Middle Aged; P-selectin; Photinia - chemistry; Plant Extracts - pharmacology; Proteins; Proteomics

The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hyperchole...