A red-fleshed apple rich in anthocyanins improves endothelial function, reduces inflammation, and modulates the immune system in hypercholesterolemic subjects: the AppleCOR study

The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hyperchole...

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Published inFood & function Vol. 15; no. 11; pp. 5825 - 5841
Main Authors Pedret, Anna, Companys, Judit, Calderón-Pérez, Lorena, Llauradó, Elisabet, Pla-Pagà, Laura, Salamanca, Patricia, Sandoval-Ramírez, Berner-Andree, Catalán, Úrsula, Fernández-Castillejo, Sara, Yuste, Silvia, Macià, Alba, Gutiérrez-Tordera, Laia, Bulló, Mónica, Camps, Jordi, Canela, Núria, Valls, Rosa Maria, Rubió-Piqué, Laura, Motilva, Maria José, Solà, Rosa
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 04.06.2024
Subjects
Acute effects
Adult
Aged
Anthocyanins
Anthocyanins - administration & dosage
Anthocyanins - pharmacology
Apples
Biomarkers
C-Reactive Protein
Complement system
Consumption
Female
Fruit - chemistry
Fruits
Health risks
Humans
Hypercholesterolemia - drug therapy
Hyperemia
Immune system
Immune System - drug effects
Immunoglobulins
Inflammation
Ischemia
Lipids
Male
Malus - chemistry
Middle Aged
P-selectin
Photinia - chemistry
Plant Extracts - pharmacology
Proteins
Proteomics
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Abstract The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose-response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption. Red-fleshed apples (RFA), improve endothelial function and decrease inflammation. RFA induce more improvements in inflammation than aronia infusion (AI), whereas AI improves lipid profile. RFA, white-fleshed apples and AI modulate immune system.
AbstractList The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose-response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption.The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose-response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption.
The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose-response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption. Red-fleshed apples (RFA), improve endothelial function and decrease inflammation. RFA induce more improvements in inflammation than aronia infusion (AI), whereas AI improves lipid profile. RFA, white-fleshed apples and AI modulate immune system.
The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose–response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption.
The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from Aronia melanocarpa (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose–response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption.
The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an infusion from (AI) with an equivalent content of ACNs as RFA, on different cardiometabolic risk biomarkers in hypercholesterolemic subjects. A randomized, parallel study was performed for 6 weeks and two dose-response studies were performed at the baseline and after intervention. At 6 weeks, RFA consumption improved ischemic reactive hyperemia and decreased C-reactive protein and interleukine-6 compared to WFA consumption. Moreover, at 6 weeks, AI decreased P-selectin compared to WFA and improved the lipid profile. Three products reduced C1q, C4 and Factor B, and RFA and AI reduced C3. Although both RFA and AI have a similar ACN content, RFA, by a matrix effect, induced more improvements in inflammation, whereas AI improved the lipid profile. Anti-inflammatory protein modulation by proteomic reduction of the complement system and immunoglobulins were verified after WFA, AI and RFA consumption.
Author Solà, Rosa
Fernández-Castillejo, Sara
Salamanca, Patricia
Bulló, Mónica
Rubió-Piqué, Laura
Yuste, Silvia
Pedret, Anna
Pla-Pagà, Laura
Sandoval-Ramírez, Berner-Andree
Llauradó, Elisabet
Valls, Rosa Maria
Gutiérrez-Tordera, Laia
Canela, Núria
Camps, Jordi
Motilva, Maria José
Companys, Judit
Catalán, Úrsula
Calderón-Pérez, Lorena
Macià, Alba
AuthorAffiliation University of Lleida
Joint Unit Universitat Rovira i Virgili-EURECAT
Faculty of Medicine and Health Sciences
Hospital Universitari Sant Joan de Reus
Agrotecnio Center
Facultat de Medicina i Ciències de la Salut
Universitat Rovira i Virgili
Unitat de Nutrició i Salut
University RoviraiVirgili (URV)
Centre for Omic Sciences (COS)
Centre Tecnològic de Catalunya
Instituto de Salud Carlos III
Escola Tècnica Superior d'Enginyeria Agrària
Functional Nutrition
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
Eurecat
IISPV
University Hospital Sant Joan
Gobierno de la Rioja
Hospital Universitari Sant Joan
Instituto de Ciencias de la Vid y del Vino (CSIC
Oxidation and Cardiovascular Diseases Group (NFOC-Salut)
Unitat de Recerca Biomèdica
XaRTA-TPV
Food Technology Department
Institute of Health Pere Virgili-IISPV
Department of Biochemistry and Biotechnology
Universidad de La Rioja
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Snippet The study determines the sustained and acute effects of a red-fleshed apple (RFA), rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and...
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SubjectTerms Acute effects
Adult
Aged
Anthocyanins
Anthocyanins - administration & dosage
Anthocyanins - pharmacology
Apples
Biomarkers
C-Reactive Protein
Complement system
Consumption
Female
Fruit - chemistry
Fruits
Health risks
Humans
Hypercholesterolemia - drug therapy
Hyperemia
Immune system
Immune System - drug effects
Immunoglobulins
Inflammation
Ischemia
Lipids
Male
Malus - chemistry
Middle Aged
P-selectin
Photinia - chemistry
Plant Extracts - pharmacology
Proteins
Proteomics
Title A red-fleshed apple rich in anthocyanins improves endothelial function, reduces inflammation, and modulates the immune system in hypercholesterolemic subjects: the AppleCOR study
URI https://www.ncbi.nlm.nih.gov/pubmed/38751340
https://www.proquest.com/docview/3064128562
https://www.proquest.com/docview/3055891860
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