Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

• Published in: Chemical communications (Cambridge, England) Vol. 56; no. 83; pp. 1253 - 12533
• Main Authors: Zhang, Hong, Xiao, Qian, Qi, Xu-Kuan, Gao, Xue-Wang, Tong, Qing-Xiao, Zhong, Jian-Ji
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 20.10.2020; Royal Society of Chemistry
• Subjects: Alkenes; Carbonyl compounds; Catalysis; Catalysts; catalytic activity; Chemistry; Chemistry, Multidisciplinary; Decarboxylation; Dehydrogenation; Ketones; Physical Sciences; redox reactions; Science & Technology; Substrates; FUNCTIONALIZATION; HYDROGEN; ACIDS; CHEMISTRY; RADICAL REACTIONS; HIGHLY EFFICIENT; WATER

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The gener...