Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The gener...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 83; pp. 1253 - 12533
Main Authors Zhang, Hong, Xiao, Qian, Qi, Xu-Kuan, Gao, Xue-Wang, Tong, Qing-Xiao, Zhong, Jian-Ji
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 20.10.2020
Royal Society of Chemistry
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Abstract A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins. The selective synthesis of allylic ketones and 1,4-dicarbonyl compounds by photoredox/cobaloxime co-catalysis and photoredox catalysis, respectively, is described herein.
AbstractList A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins. The selective synthesis of allylic ketones and 1,4-dicarbonyl compounds by photoredox/cobaloxime co-catalysis and photoredox catalysis, respectively, is described herein.
A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.
A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.
A photoredox/cobaloxime co-catalyzed coupling reaction of a-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.
Author Tong, Qing-Xiao
Zhang, Hong
Gao, Xue-Wang
Xiao, Qian
Qi, Xu-Kuan
Zhong, Jian-Ji
AuthorAffiliation Key Laboratory of Photochemical Conversion and Optoelectronic Materials
Shantou University, and Chemistry and Chemical Engineering Laboratory of Guangdong Province
Chinese Academy of Sciences
Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province
Technical Institute of Physics and Chemistry
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– name: Chinese Academy of Sciences
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WATER
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Snippet A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime...
A photoredox/cobaloxime co-catalyzed coupling reaction of a-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime...
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SubjectTerms Alkenes
Carbonyl compounds
Catalysis
Catalysts
catalytic activity
Chemistry
Chemistry, Multidisciplinary
Decarboxylation
Dehydrogenation
Ketones
Physical Sciences
redox reactions
Science & Technology
Substrates
Title Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis
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