Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands

Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/ 2b derived from ( R)/( S)-phenylglycinol or enantioselective reduction of 4-[η 6-chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborol...

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 9; no. 22; pp. 3963 - 3966
Main Authors Delorme, Daniel, Berthelette, Carl, Lavoie, Rico, Roberts, Edward
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 27.11.1998
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
ORGANOMETALLICS
PRIMARY AMINE
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Summary:Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/ 2b derived from ( R)/( S)-phenylglycinol or enantioselective reduction of 4-[η 6-chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborolidine followed by amine introduction to furnish optically active diarylmethylamines.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(98)00419-4