Ganglioside GM3 deficiency enhances mast cell sensitivity

• Published in: The FEBS journal Vol. 290; no. 17; pp. 4268 - 4280
• Main Authors: Komuro, Mariko, Mizugaki, Hinano, Nagane, Masaki, Morimoto, Misako, Fukuyama, Tomoki, Ogihara, Kikumi, Naya, Yuko, Yokomori, Emi, Kaneshima, Kimika, Kawakami, Yasushi, Kamiie, Junichi, Shibata, Yuki, Suzuki, Mira, Shimizu, Takuto, Kawashima, Nagako, Okamoto, Mariko, Ikeda, Teruo, Yamashita, Tadashi
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2023
• Subjects: Allergic reactions; Bone marrow; Cell membranes; Chemokines; Complex lipids; Cytokines; eukaryotic cells; Ganglioside GM3; Gangliosides; Hypersensitivity; Inflammation; Integrity; Kinases; Lactosylceramide a-2,3-sialyltransferase; Lipid rafts; Lipids; Mast cells; Membranes; mitogen-activated protein kinase; Phosphorylation; Sensitivity enhancement; Signal transduction; Skin; sugars; topology; Transplantation; mast cell; membrane integrity; dermatitis; ganglioside GM3; p38 MAPK

Mast cells are a significant source of cytokines and chemokines that play a role in pathological processes. Gangliosides, which are complex lipids with a sugar chain, are present in all eukaryotic cell membranes and comprise lipid rafts. Ganglioside GM3, the first ganglioside in the synthetic pathwa...