Design, synthesis, and inhibitory activity of hydroquinone ester derivatives against mushroom tyrosinase

• Published in: RSC advances Vol. 14; no. 9; pp. 685 - 695
• Main Authors: Xie, Dong, Han, Kangjia, Jiang, Qian, Xie, Sida, Zhou, Jielong, Zhang, Yingjun, Xu, Junming, He, Yuanping, Zhao, Ping, Yang, Xiaoqin
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.02.2024
• Subjects: Amino acids; Analogs; Catalytic activity; Copper; Enzymes; Hydroquinone; Molecular docking; Molecular dynamics; Mushrooms; Substrates; Synthesis; Toxicity; Tyrosinase

Tyrosinase is a widely distributed copper-containing enzyme found in various organisms, playing a crucial role in the process of melanin production. Inhibiting its activity can reduce skin pigmentation. Hydroquinone is an efficient inhibitor of tyrosinase, but its safety has been a subject of debate...