Effects of Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate (HMB) on Biochemical and Hematological Indices in Community-Dwelling Older Adults at Risk of Malnutrition: Findings from the SHIELD Study
Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Streng...
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| Published in | Nutrients Vol. 16; no. 15; p. 2495 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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MDPI AG
01.08.2024
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| Abstract | Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D
, and 0.74 g calcium β-hydroxy-β-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L,
< 0.001), urea to creatinine ratio (4.39 vs. 4.26,
< 0.001), prealbumin (24.9 mg/dL vs. 24.0 mg/dL,
< 0.001), vitamin B
(480.0 pmol/L vs. 420.1 pmol/L,
< 0.001), and globulin levels (26.8 g/L vs. 26.5 g/L,
= 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 × 10
/µL vs. 58.2 × 10
/µL, overall
< 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall
= 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g/L vs. 71.1 g/L,
= 0.017) and in absolute monocyte count at day 90 (0.50 × 10
/µL vs. 0.47 × 10
/µL,
= 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. |
|---|---|
| AbstractList | Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D3, and 0.74 g calcium β-hydroxy-β-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L, p < 0.001), urea to creatinine ratio (4.39 vs. 4.26, p < 0.001), prealbumin (24.9 mg/dL vs. 24.0 mg/dL, p < 0.001), vitamin B12 (480.0 pmol/L vs. 420.1 pmol/L, p < 0.001), and globulin levels (26.8 g/L vs. 26.5 g/L, p = 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 × 103/µL vs. 58.2 × 103/µL, overall p < 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall p = 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g/L vs. 71.1 g/L, p = 0.017) and in absolute monocyte count at day 90 (0.50 × 103/µL vs. 0.47 × 103/µL, p = 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D[sub.3], and 0.74 g calcium β-hydroxy-β-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L, p < 0.001), urea to creatinine ratio (4.39 vs. 4.26, p < 0.001), prealbumin (24.9 mg/dL vs. 24.0 mg/dL, p < 0.001), vitamin B[sub.12] (480.0 pmol/L vs. 420.1 pmol/L, p < 0.001), and globulin levels (26.8 g/L vs. 26.5 g/L, p = 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 × 10[sup.3]/µL vs. 58.2 × 10[sup.3]/µL, overall p < 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall p = 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g/L vs. 71.1 g/L, p = 0.017) and in absolute monocyte count at day 90 (0.50 × 10[sup.3]/µL vs. 0.47 × 10[sup.3]/µL, p = 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D , and 0.74 g calcium β-hydroxy-β-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L, < 0.001), urea to creatinine ratio (4.39 vs. 4.26, < 0.001), prealbumin (24.9 mg/dL vs. 24.0 mg/dL, < 0.001), vitamin B (480.0 pmol/L vs. 420.1 pmol/L, < 0.001), and globulin levels (26.8 g/L vs. 26.5 g/L, = 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 × 10 /µL vs. 58.2 × 10 /µL, overall < 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall = 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g/L vs. 71.1 g/L, = 0.017) and in absolute monocyte count at day 90 (0.50 × 10 /µL vs. 0.47 × 10 /µL, = 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D3, and 0.74 g calcium β-hydroxy-β-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L, p < 0.001), urea to creatinine ratio (4.39 vs. 4.26, p < 0.001), prealbumin (24.9 mg/dL vs. 24.0 mg/dL, p < 0.001), vitamin B12 (480.0 pmol/L vs. 420.1 pmol/L, p < 0.001), and globulin levels (26.8 g/L vs. 26.5 g/L, p = 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 × 103/µL vs. 58.2 × 103/µL, overall p < 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall p = 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g/L vs. 71.1 g/L, p = 0.017) and in absolute monocyte count at day 90 (0.50 × 103/µL vs. 0.47 × 103/µL, p = 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition.Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 µg vitamin D3, and 0.74 g calcium β-hydroxy-β-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol/L vs. 5.4 mmol/L, p < 0.001), urea to creatinine ratio (4.39 vs. 4.26, p < 0.001), prealbumin (24.9 mg/dL vs. 24.0 mg/dL, p < 0.001), vitamin B12 (480.0 pmol/L vs. 420.1 pmol/L, p < 0.001), and globulin levels (26.8 g/L vs. 26.5 g/L, p = 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 × 103/µL vs. 58.2 × 103/µL, overall p < 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall p = 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g/L vs. 71.1 g/L, p = 0.017) and in absolute monocyte count at day 90 (0.50 × 103/µL vs. 0.47 × 103/µL, p = 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. |
| Audience | Academic |
| Author | Chew, Samuel Teong Huang Cheong, Magdalin Oliver, Jeffery Chow, Wai Leng Tey, Siew Ling Baggs, Geraldine Kong, Sing Teang Huynh, Dieu Thi Thu How, Choon How Aw, Tar Choon Tan, Ngiap Chuan Low, Yen Ling |
| Author_xml | – sequence: 1 givenname: Siew Ling orcidid: 0000-0002-5064-5283 surname: Tey fullname: Tey, Siew Ling organization: Abbott Nutrition Research and Development, Singapore 138668, Singapore – sequence: 2 givenname: Dieu Thi Thu surname: Huynh fullname: Huynh, Dieu Thi Thu organization: Abbott Nutrition Research and Development, Singapore 138668, Singapore – sequence: 3 givenname: Sing Teang orcidid: 0000-0002-4595-4428 surname: Kong fullname: Kong, Sing Teang organization: Abbott Nutrition Research and Development, Singapore 138668, Singapore – sequence: 4 givenname: Jeffery surname: Oliver fullname: Oliver, Jeffery organization: Abbott Nutrition Research and Development, Columbus, OH 43219, USA – sequence: 5 givenname: Geraldine orcidid: 0000-0001-9419-7040 surname: Baggs fullname: Baggs, Geraldine organization: Abbott Nutrition Research and Development, Columbus, OH 43219, USA – sequence: 6 givenname: Yen Ling surname: Low fullname: Low, Yen Ling organization: Abbott Nutrition Research and Development, Singapore 138668, Singapore – sequence: 7 givenname: Choon How surname: How fullname: How, Choon How organization: Care and Health Integration, Changi General Hospital, Singapore 529889, Singapore – sequence: 8 givenname: Magdalin surname: Cheong fullname: Cheong, Magdalin organization: Department of Dietetic & Food Services, Changi General Hospital, Singapore 529889, Singapore – sequence: 9 givenname: Wai Leng surname: Chow fullname: Chow, Wai Leng organization: Health Services Research, Changi General Hospital, Singapore 529889, Singapore – sequence: 10 givenname: Ngiap Chuan surname: Tan fullname: Tan, Ngiap Chuan organization: SingHealth Polyclinics, Singapore 150167, Singapore – sequence: 11 givenname: Tar Choon orcidid: 0000-0002-7814-8836 surname: Aw fullname: Aw, Tar Choon organization: Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore – sequence: 12 givenname: Samuel Teong Huang orcidid: 0000-0003-2810-1332 surname: Chew fullname: Chew, Samuel Teong Huang organization: Department of Geriatric Medicine, Changi General Hospital, Singapore 529889, Singapore |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39125374$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3390/nu13030835 10.1002/jpen.2534 10.1111/jhn.12241 10.1079/BJN20041258 10.1177/0004563220931885 10.1177/2010105820964829 10.1016/j.arr.2023.101953 10.1182/blood.V69.2.522.522 10.3390/nu13082764 10.1016/j.clnu.2020.10.015 10.1093/ajcn/nqy373 10.3389/fmed.2021.681232 10.2147/CIA.S405847 10.1093/nutrit/nuac062 10.3390/nu14112344 10.1016/j.clnu.2015.12.010 10.1016/0895-4356(93)90053-4 10.1016/S0895-4356(99)00049-9 10.1093/ajcn/25.5.539 10.1161/01.ATV.19.3.672 10.3390/nu11040895 10.1038/s41430-021-00977-4 10.1093/ageing/afac147 10.3390/healthcare8020151 10.3390/nu9080829 10.1016/j.clnu.2022.01.024 10.3390/nu13124355 10.3390/jcm8060775 10.1016/j.jamda.2016.08.009 10.1093/ageing/23.1.40 10.7326/0003-4819-150-9-200905050-00006 10.1186/s12877-022-03704-1 10.1186/s12877-019-1148-5 10.1016/j.clnu.2018.11.021 10.1016/j.nut.2004.01.004 10.1016/S0140-6736(22)02612-5 10.1016/j.clnu.2022.07.041 10.21037/jlpm-23-15 10.1007/s12603-018-1153-y 10.3390/nu14061196 10.1136/bmj.g5226 10.3390/nu8020069 10.1007/s12603-021-1665-8 10.1001/jamanetworkopen.2020.0663 10.1371/journal.pone.0141757 10.1016/0895-4356(89)90065-6 10.1016/j.clnu.2020.08.031 10.1038/nrdp.2017.40 10.1016/j.maturitas.2017.04.010 10.1016/S0140-6736(18)32776-4 10.1123/ijsnem.13.2.184 10.1249/MSS.0000000000000975 10.1093/advances/nmaa108 10.1016/0021-9681(87)90171-8 10.1155/2018/9858252 10.1056/NEJMra2212159 10.1002/ncp.10588 10.1002/jcsm.12208 10.1007/s12603-023-1993-y 10.1016/j.clnu.2023.09.004 10.1152/japplphysiol.00045.2014 10.1002/14651858.CD002008.pub5 10.1016/j.arr.2019.02.005 10.1001/jama.1974.03230140015003 10.1007/s12603-021-1621-7 10.1007/s12603-023-2011-0 10.1111/ijlh.12500 10.1080/07315724.1999.10718881 10.1007/s12603-019-1273-z 10.1093/jn/16.6.597 10.1016/j.arr.2020.101137 10.1186/s12877-021-02240-8 10.1155/2021/6639935 10.1016/j.ajcnut.2023.08.015 10.1016/j.nut.2020.110933 10.1016/j.jamda.2019.12.012 |
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| Keywords | oral nutritional supplement malnutrition hematological indices older adults biochemical indices β-hydroxy-β-methylbutyrate (HMB) aging |
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| References | Dent (ref_18) 2019; 23 Huynh (ref_60) 2015; 28 Simmons (ref_68) 1972; 25 ref_14 ref_12 ref_56 Merker (ref_75) 2020; 3 Lin (ref_16) 2023; 27 Deutz (ref_31) 2016; 35 Ranasinghe (ref_57) 2022; 59 ref_15 Green (ref_77) 2017; 3 Ahmad (ref_5) 2021; 2021 Higashiguchi (ref_8) 2017; 26 Prado (ref_26) 2022; 41 Charlson (ref_52) 1987; 40 Washburn (ref_53) 1993; 46 ref_24 Veronese (ref_37) 2019; 51 Izquierdo (ref_25) 2021; 25 Baldwin (ref_34) 2021; 12 ref_21 Deutz (ref_64) 2021; 40 ref_65 Halaweh (ref_4) 2018; 2018 ref_62 Kushwaha (ref_10) 2020; 63 Shah (ref_51) 1989; 42 Levey (ref_55) 2009; 150 Mikton (ref_2) 2022; 51 Cawood (ref_35) 2023; 88 Konecka (ref_48) 2022; 26 Washburn (ref_54) 1999; 52 Bear (ref_38) 2019; 109 Wong (ref_11) 2021; 30 Dent (ref_29) 2023; 401 ref_72 Cramer (ref_44) 2016; 17 Neumann (ref_67) 2004; 20 ref_71 Kopple (ref_70) 1974; 227 Tong (ref_86) 1987; 69 Landi (ref_19) 2019; 38 Volkert (ref_27) 2022; 41 Buttarello (ref_82) 2016; 38 ref_36 Powers (ref_22) 2016; 48 ref_79 Chew (ref_30) 2021; 40 (ref_40) 2017; 8 ref_33 Hirsch (ref_66) 1999; 18 ref_76 Robinson (ref_20) 2023; 118 Oktaviana (ref_39) 2019; 23 Wunderle (ref_73) 2024; 48 Peng (ref_45) 2021; 25 Pourhassan (ref_74) 2022; 76 Huynh (ref_9) 2023; 18 Noe (ref_13) 2020; 79–80 Aragon (ref_23) 2022; 81 Baggs (ref_41) 2023; 42 ref_81 Malafarina (ref_59) 2017; 101 Clark (ref_69) 2014; 116 ref_47 Crowe (ref_85) 2003; 13 ref_46 Alt (ref_83) 1938; 16 ref_43 Chuansangeam (ref_7) 2022; 31 ref_42 ref_84 ref_1 Schuetz (ref_32) 2019; 393 ref_3 Evans (ref_58) 2021; 36 Hunt (ref_78) 2014; 349 Martin (ref_87) 1999; 19 ref_49 Chen (ref_63) 2020; 21 Cederholm (ref_28) 2024; 391 Woo (ref_61) 1994; 23 Duvall (ref_80) 2023; 8 Rolland (ref_17) 2023; 27 ref_6 Stratton (ref_50) 2004; 92 |
| References_xml | – ident: ref_36 doi: 10.3390/nu13030835 – volume: 48 start-page: 27 year: 2024 ident: ref_73 article-title: Inflammation and response to nutrition interventions publication-title: J. Parenter. Enter. Nutr. doi: 10.1002/jpen.2534 contributor: fullname: Wunderle – volume: 28 start-page: 331 year: 2015 ident: ref_60 article-title: Effects of oral nutritional supplementation in the management of malnutrition in hospital and post-hospital discharged patients in India: A randomised, open-label, controlled trial publication-title: J. Hum. Nutr. Diet. doi: 10.1111/jhn.12241 contributor: fullname: Huynh – volume: 92 start-page: 799 year: 2004 ident: ref_50 article-title: Malnutrition in hospital outpatients and inpatients: Prevalence, concurrent validity and ease of use of the ‘Malnutrition Universal Screening Tool’ (‘MUST’) for adults publication-title: Br. J. Nutr. doi: 10.1079/BJN20041258 contributor: fullname: Stratton – volume: 59 start-page: 7 year: 2022 ident: ref_57 article-title: Prealbumin: The clinical utility and analytical methodologies publication-title: Ann. Clin. Biochem. doi: 10.1177/0004563220931885 contributor: fullname: Ranasinghe – volume: 30 start-page: 225 year: 2021 ident: ref_11 article-title: Adult malnutrition, nutritional interventions and outcomes in Singapore: A scoping review of local studies for the past 20 years publication-title: Proc. Singap. Healthc. doi: 10.1177/2010105820964829 contributor: fullname: Wong – volume: 88 start-page: 101953 year: 2023 ident: ref_35 article-title: A systematic review and meta-analysis of the effects of community use of oral nutritional supplements on clinical outcomes publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2023.101953 contributor: fullname: Cawood – ident: ref_84 – volume: 69 start-page: 522 year: 1987 ident: ref_86 article-title: Proplatelets and stress platelets publication-title: Blood doi: 10.1182/blood.V69.2.522.522 contributor: fullname: Tong – ident: ref_14 doi: 10.3390/nu13082764 – volume: 40 start-page: 1879 year: 2021 ident: ref_30 article-title: Impact of specialized oral nutritional supplement on clinical, nutritional, and functional outcomes: A randomized, placebo-controlled trial in community-dwelling older adults at risk of malnutrition publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2020.10.015 contributor: fullname: Chew – volume: 109 start-page: 1119 year: 2019 ident: ref_38 article-title: β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: A systematic review and meta-analysis publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/nqy373 contributor: fullname: Bear – ident: ref_21 doi: 10.3389/fmed.2021.681232 – volume: 18 start-page: 677 year: 2023 ident: ref_9 article-title: Malnutrition, frailty, and health-related quality of life among rural older adults in Vietnam: A cross-sectional study publication-title: Clin. Interv. Aging doi: 10.2147/CIA.S405847 contributor: fullname: Huynh – volume: 81 start-page: 441 year: 2022 ident: ref_23 article-title: Age-related muscle anabolic resistance: Inevitable or preventable? publication-title: Nutr. Rev. doi: 10.1093/nutrit/nuac062 contributor: fullname: Aragon – ident: ref_65 doi: 10.3390/nu14112344 – volume: 35 start-page: 18 year: 2016 ident: ref_31 article-title: Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2015.12.010 contributor: fullname: Deutz – volume: 46 start-page: 153 year: 1993 ident: ref_53 article-title: The Physical Activity Scale for the Elderly (PASE): Development and evaluation publication-title: J. Clin. Epidemiol. doi: 10.1016/0895-4356(93)90053-4 contributor: fullname: Washburn – ident: ref_1 – volume: 52 start-page: 643 year: 1999 ident: ref_54 article-title: The Physical Activity Scale for the Elderly (PASE): Evidence for validity publication-title: J. Clin. Epidemiol. doi: 10.1016/S0895-4356(99)00049-9 contributor: fullname: Washburn – volume: 25 start-page: 539 year: 1972 ident: ref_68 article-title: Urinary urea nitrogen-creatinine ratio as indicator of recent protein intake in field studies publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/25.5.539 contributor: fullname: Simmons – volume: 19 start-page: 672 year: 1999 ident: ref_87 article-title: A role for changes in platelet production in the cause of acute coronary syndromes publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.19.3.672 contributor: fullname: Martin – ident: ref_56 doi: 10.3390/nu11040895 – ident: ref_71 – volume: 26 start-page: 202 year: 2017 ident: ref_8 article-title: Taking action against malnutrition in Asian healthcare settings: An initiative of a Northeast Asia Study Group publication-title: Asia Pac. J. Clin. Nutr. contributor: fullname: Higashiguchi – volume: 76 start-page: 397 year: 2022 ident: ref_74 article-title: Inflammation as a diagnostic criterion in the GLIM definition of malnutrition—What CRP-threshold relates to reduced food intake in older patients with acute disease? publication-title: Eur. J. Clin. Nutr. doi: 10.1038/s41430-021-00977-4 contributor: fullname: Pourhassan – volume: 51 start-page: afac147 year: 2022 ident: ref_2 article-title: The UN Decade of healthy ageing: Strengthening measurement for monitoring health and wellbeing of older people publication-title: Age Ageing doi: 10.1093/ageing/afac147 contributor: fullname: Mikton – ident: ref_6 doi: 10.3390/healthcare8020151 – ident: ref_46 doi: 10.3390/nu9080829 – volume: 41 start-page: 958 year: 2022 ident: ref_27 article-title: ESPEN practical guideline: Clinical nutrition and hydration in geriatrics publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2022.01.024 contributor: fullname: Volkert – ident: ref_43 doi: 10.3390/nu13124355 – ident: ref_47 doi: 10.3390/jcm8060775 – volume: 17 start-page: 1044 year: 2016 ident: ref_44 article-title: Impacts of high-protein oral nutritional supplements among malnourished men and women with sarcopenia: A multicenter, randomized, double-blinded, controlled trial publication-title: J. Am. Med. Dir. Assoc. doi: 10.1016/j.jamda.2016.08.009 contributor: fullname: Cramer – volume: 23 start-page: 40 year: 1994 ident: ref_61 article-title: Nutritional status of elderly patients during recovery from chest infection and the role of nutritional supplementation assessed by a prospective randomized single-blind trial publication-title: Age Ageing doi: 10.1093/ageing/23.1.40 contributor: fullname: Woo – volume: 150 start-page: 604 year: 2009 ident: ref_55 article-title: A new equation to estimate glomerular filtration rate publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-150-9-200905050-00006 contributor: fullname: Levey – ident: ref_62 doi: 10.1186/s12877-022-03704-1 – ident: ref_12 doi: 10.1186/s12877-019-1148-5 – volume: 38 start-page: 2113 year: 2019 ident: ref_19 article-title: Muscle loss: The new malnutrition challenge in clinical practice publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2018.11.021 contributor: fullname: Landi – volume: 20 start-page: 415 year: 2004 ident: ref_67 article-title: Provision of high-protein supplement for patients recovering from hip fracture publication-title: Nutrition doi: 10.1016/j.nut.2004.01.004 contributor: fullname: Neumann – volume: 401 start-page: 951 year: 2023 ident: ref_29 article-title: Malnutrition in older adults publication-title: Lancet doi: 10.1016/S0140-6736(22)02612-5 contributor: fullname: Dent – volume: 41 start-page: 2244 year: 2022 ident: ref_26 article-title: Advances in muscle health and nutrition: A toolkit for healthcare professionals publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2022.07.041 contributor: fullname: Prado – volume: 8 start-page: 19 year: 2023 ident: ref_80 article-title: Investigative algorithms for disorders affecting plasma proteins with a focus on albumin and the calculated globulin fraction: A narrative review publication-title: J. Lab. Precis. Med. doi: 10.21037/jlpm-23-15 contributor: fullname: Duvall – volume: 23 start-page: 145 year: 2019 ident: ref_39 article-title: The effect of beta-hydroxy-beta-methylbutyrate (HMB) on sarcopenia and functional frailty in older persons: A systematic review publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-018-1153-y contributor: fullname: Oktaviana – volume: 31 start-page: 128 year: 2022 ident: ref_7 article-title: Prevalence and risk for malnutrition in older Thai people: A systematic review and meta-analysis publication-title: Asia Pac. J. Clin. Nutr. contributor: fullname: Chuansangeam – ident: ref_49 doi: 10.3390/nu14061196 – volume: 349 start-page: g5226 year: 2014 ident: ref_78 article-title: Vitamin B12 deficiency publication-title: BMJ Br. Med. J. doi: 10.1136/bmj.g5226 contributor: fullname: Hunt – ident: ref_72 – ident: ref_15 doi: 10.3390/nu8020069 – volume: 25 start-page: 824 year: 2021 ident: ref_25 article-title: International exercise recommendations in older adults (ICFSR): Expert consensus guidelines publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-021-1665-8 contributor: fullname: Izquierdo – volume: 3 start-page: e200663 year: 2020 ident: ref_75 article-title: Association of Baseline Inflammation With Effectiveness of Nutritional Support Among Patients With Disease-Related Malnutrition: A Secondary Analysis of a Randomized Clinical Trial publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2020.0663 contributor: fullname: Merker – ident: ref_42 doi: 10.1371/journal.pone.0141757 – volume: 42 start-page: 703 year: 1989 ident: ref_51 article-title: Improving the sensitivity of the Barthel Index for stroke rehabilitation publication-title: J. Clin. Epidemiol. doi: 10.1016/0895-4356(89)90065-6 contributor: fullname: Shah – ident: ref_76 – volume: 40 start-page: 1388 year: 2021 ident: ref_64 article-title: Reduced mortality risk in malnourished hospitalized older adult patients with COPD treated with a specialized oral nutritional supplement: Sub-group analysis of the NOURISH study publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2020.08.031 contributor: fullname: Deutz – ident: ref_3 – volume: 3 start-page: 17040 year: 2017 ident: ref_77 article-title: Vitamin B12 deficiency publication-title: Nat. Rev. Dis. Primers doi: 10.1038/nrdp.2017.40 contributor: fullname: Green – volume: 101 start-page: 42 year: 2017 ident: ref_59 article-title: Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial publication-title: Maturitas doi: 10.1016/j.maturitas.2017.04.010 contributor: fullname: Malafarina – volume: 393 start-page: 2312 year: 2019 ident: ref_32 article-title: Individualised nutritional support in medical inpatients at nutritional risk: A randomised clinical trial publication-title: Lancet doi: 10.1016/S0140-6736(18)32776-4 contributor: fullname: Schuetz – volume: 13 start-page: 184 year: 2003 ident: ref_85 article-title: The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on indices of health in highly trained athletes publication-title: Int. J. Sport Nutr. Exerc. Metab. doi: 10.1123/ijsnem.13.2.184 contributor: fullname: Crowe – volume: 48 start-page: 2307 year: 2016 ident: ref_22 article-title: Disease-induced skeletal muscle atrophy and fatigue publication-title: Med. Sci. Sports Exerc. doi: 10.1249/MSS.0000000000000975 contributor: fullname: Powers – volume: 12 start-page: 503 year: 2021 ident: ref_34 article-title: Quality of the evidence supporting the role of oral nutritional supplements in the management of malnutrition: An overview of systematic reviews and meta-analyses publication-title: Adv. Nutr. doi: 10.1093/advances/nmaa108 contributor: fullname: Baldwin – volume: 40 start-page: 373 year: 1987 ident: ref_52 article-title: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation publication-title: J. Chronic Dis. doi: 10.1016/0021-9681(87)90171-8 contributor: fullname: Charlson – ident: ref_79 – volume: 2018 start-page: 9858252 year: 2018 ident: ref_4 article-title: Perspectives of older adults on aging well: A focus group study publication-title: J. Aging Res. doi: 10.1155/2018/9858252 contributor: fullname: Halaweh – volume: 391 start-page: 155 year: 2024 ident: ref_28 article-title: Malnutrition in adults publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra2212159 contributor: fullname: Cederholm – volume: 36 start-page: 22 year: 2021 ident: ref_58 article-title: The Use of Visceral Proteins as Nutrition Markers: An ASPEN Position Paper publication-title: Nutr. Clin. Pract. doi: 10.1002/ncp.10588 contributor: fullname: Evans – volume: 8 start-page: 529 year: 2017 ident: ref_40 article-title: Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions publication-title: J. Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12208 – ident: ref_81 – volume: 27 start-page: 797 year: 2023 ident: ref_16 article-title: Untangling the complex interplay between social isolation, anorexia, sarcopenia, and mortality: Insights from a longitudinal study publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-023-1993-y contributor: fullname: Lin – volume: 42 start-page: 2116 year: 2023 ident: ref_41 article-title: Impact of a specialized oral nutritional supplement on quality of life in older adults following hospitalization: Post-hoc analysis of the NOURISH trial publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2023.09.004 contributor: fullname: Baggs – volume: 116 start-page: 1605 year: 2014 ident: ref_69 article-title: Total body skeletal muscle mass: Estimation by creatine (methyl-d3) dilution in humans publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00045.2014 contributor: fullname: Clark – ident: ref_33 doi: 10.1002/14651858.CD002008.pub5 – volume: 51 start-page: 48 year: 2019 ident: ref_37 article-title: Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2019.02.005 contributor: fullname: Veronese – volume: 227 start-page: 41 year: 1974 ident: ref_70 article-title: Evaluation of chronic uremia: Importance of serum urea nitrogen, serum creatinine, and their ratio publication-title: JAMA doi: 10.1001/jama.1974.03230140015003 contributor: fullname: Kopple – volume: 25 start-page: 767 year: 2021 ident: ref_45 article-title: Oral nutritional supplement with β-hydroxy-β-methylbutyrate (HMB) improves nutrition, physical performance and ameliorates intramuscular adiposity in pre-frail older adults: A randomized controlled trial publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-021-1621-7 contributor: fullname: Peng – volume: 27 start-page: 794 year: 2023 ident: ref_17 article-title: Social isolation and loneliness: Overlooked therapeutic targets of anorexia of aging? publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-023-2011-0 contributor: fullname: Rolland – volume: 38 start-page: 123 year: 2016 ident: ref_82 article-title: Laboratory diagnosis of anemia: Are the old and new red cell parameters useful in classification and treatment, how? publication-title: Int. J. Lab. Hematol. doi: 10.1111/ijlh.12500 contributor: fullname: Buttarello – volume: 18 start-page: 434 year: 1999 ident: ref_66 article-title: Nutritional support in alcoholic cirrhotic patients improves host defenses publication-title: J. Am. Coll. Nutr. doi: 10.1080/07315724.1999.10718881 contributor: fullname: Hirsch – volume: 23 start-page: 771 year: 2019 ident: ref_18 article-title: Physical frailty: ICFSR international clinical practice guidelines for identification and management publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-019-1273-z contributor: fullname: Dent – volume: 16 start-page: 597 year: 1938 ident: ref_83 article-title: The relation of growth and nutrition to the reticulocyte level in the young rat: Three figures publication-title: J. Nutr. doi: 10.1093/jn/16.6.597 contributor: fullname: Alt – volume: 26 start-page: 5144 year: 2022 ident: ref_48 article-title: Analysis of the laboratory results of the patients enrolled in the Nutritional Therapy Program publication-title: Eur. Rev. Med. Pharmacol. Sci. contributor: fullname: Konecka – volume: 63 start-page: 101137 year: 2020 ident: ref_10 article-title: Estimates of malnutrition and risk of malnutrition among the elderly (≥60 years) in India: A systematic review and meta-analysis publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2020.101137 contributor: fullname: Kushwaha – ident: ref_24 doi: 10.1186/s12877-021-02240-8 – volume: 2021 start-page: 6639935 year: 2021 ident: ref_5 article-title: Malnutrition among the elderly in Malaysia and its associated factors: Findings from the National Health and Morbidity Survey 2018 publication-title: J. Nutr. Metab. doi: 10.1155/2021/6639935 contributor: fullname: Ahmad – volume: 118 start-page: 852 year: 2023 ident: ref_20 article-title: The role of nutrition in the prevention of sarcopenia publication-title: Am. J. Clin. Nutr. doi: 10.1016/j.ajcnut.2023.08.015 contributor: fullname: Robinson – volume: 79–80 start-page: 110933 year: 2020 ident: ref_13 article-title: Assessment of nutritional status and risk factors for malnutrition among the elderly in Loikaw, Myanmar publication-title: Nutrition doi: 10.1016/j.nut.2020.110933 contributor: fullname: Noe – volume: 21 start-page: 300 year: 2020 ident: ref_63 article-title: Asian Working Group for Sarcopenia: 2019 Consensus update on sarcopenia diagnosis and treatment publication-title: J. Am. Med. Dir. Assoc. doi: 10.1016/j.jamda.2019.12.012 contributor: fullname: Chen |
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