Temperature- and capsaicin-sensitive nerve fibers in brown adipose tissue attenuate thermogenesis in the rat

• Published in: Pflügers Archiv Vol. 437; no. 1; pp. 36 - 42
• Main Authors: Osaka, T, Kobayashi, A, Namba, Y, Ezaki, O, Inoue, S, Kimura, S, Lee, T H
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.12.1998
• Subjects: Adipocytes; Adipose Tissue, Brown - innervation; Animals; Body Temperature Regulation - physiology; Calcitonin Gene-Related Peptide - pharmacology; Capsaicin - pharmacology; Denervation; Female; Hot Temperature; Nerve Fibers - drug effects; Nerve Fibers - physiology; Norepinephrine - pharmacology; Rats; Rats, Sprague-Dawley; Rodents; Substance P - pharmacology; Temperature

We examined the function of putative sensory fibers that are contained in intercostal nerves and innervate interscapular brown adipose tissue (IBAT) in urethane-anesthetized rats. Warming the IBAT to 40-44 degrees C with two small heaters placed bilaterally on the skin above it attenuated the subseq...