Involvement of cytotoxic Eomes-expressing CD4⁺ T cells in secondary progressive multiple sclerosis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 11; pp. 1 - 12
• Main Authors: Raveney, Ben J. E., Sato, Wakiro, Takewaki, Daiki, Zhang, Chenyang, Kanazawa, Tomomi, Lin, Youwei, Okamoto, Tomoko, Araki, Manabu, Kimura, Yukio, Sato, Noriko, Sano, Terunori, Saito, Yuko, Oki, Shinji, Yamamura, Takashi
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 16.03.2021
• Subjects: Autoimmune diseases; Autopsies; Autopsy; Biological Sciences; Biomarkers; CD4 antigen; Central nervous system; Cytotoxicity; Granzyme B; Health risks; Helper cells; Inflammation; Lymphocytes; Lymphocytes T; Multiple sclerosis; Neurological diseases; Pathogenesis; Peripheral blood; Risk assessment; Signs and symptoms; Therapeutic targets; autoimmunity; secondary progressive multiple sclerosis; Eomes+ Th cells; biomarkers; multiple sclerosis

Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes of peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to a chronic dise...