Effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves on liver function in excessive drinkers: A randomized, double-blind, placebo-controlled trial
[Display omitted] •GGT significantly decreased in the women PLC group compared with the placebo group.•TC, LDL-C, and HDL-C significantly decreased in the PLC group after 12-weeks.•Some item of FSS questionnaire improved in PLC group after 12-weeks.•No adverse event and safety issue for 12-week inta...
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| Published in | Journal of functional foods Vol. 83; p. 104535 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
01.08.2021
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| Abstract | [Display omitted]
•GGT significantly decreased in the women PLC group compared with the placebo group.•TC, LDL-C, and HDL-C significantly decreased in the PLC group after 12-weeks.•Some item of FSS questionnaire improved in PLC group after 12-weeks.•No adverse event and safety issue for 12-week intake PLC.
Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves (PLC) on liver function in Korean. A randomized, double-blind, placebo-controlled study was performed in 50 excessive drinkers. The subjects were randomly assigned to PLC (n = 25, 2,000 mg/day) or placebo (n = 25) groups. Blood liver enzymes, lipid profiles, and antioxidant enzymes were assessed at baseline and 12 weeks. GGT level significantly decreased in women in the test group compared with the placebo group (-2.50 ± 3.54 U/L vs. 3.80 ± 11.23 U/L, P = 0.006). TC (-13.04 ± 25.65 mg/dL, P = 0.020) and LDL-C (-10.33 ± 24.15 mg/dL, P = 0.047) levels reduced in the test group after 12 weeks. Although PLC, appears the possibility of improving liver function in excessive drinkers, however, a larger scale and long-term intervention study should be performed. |
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| AbstractList | [Display omitted]
•GGT significantly decreased in the women PLC group compared with the placebo group.•TC, LDL-C, and HDL-C significantly decreased in the PLC group after 12-weeks.•Some item of FSS questionnaire improved in PLC group after 12-weeks.•No adverse event and safety issue for 12-week intake PLC.
Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves (PLC) on liver function in Korean. A randomized, double-blind, placebo-controlled study was performed in 50 excessive drinkers. The subjects were randomly assigned to PLC (n = 25, 2,000 mg/day) or placebo (n = 25) groups. Blood liver enzymes, lipid profiles, and antioxidant enzymes were assessed at baseline and 12 weeks. GGT level significantly decreased in women in the test group compared with the placebo group (-2.50 ± 3.54 U/L vs. 3.80 ± 11.23 U/L, P = 0.006). TC (-13.04 ± 25.65 mg/dL, P = 0.020) and LDL-C (-10.33 ± 24.15 mg/dL, P = 0.047) levels reduced in the test group after 12 weeks. Although PLC, appears the possibility of improving liver function in excessive drinkers, however, a larger scale and long-term intervention study should be performed. Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves (PLC) on liver function in Korean. A randomized, double-blind, placebo-controlled study was performed in 50 excessive drinkers. The subjects were randomly assigned to PLC (n = 25, 2,000 mg/day) or placebo (n = 25) groups. Blood liver enzymes, lipid profiles, and antioxidant enzymes were assessed at baseline and 12 weeks. GGT level significantly decreased in women in the test group compared with the placebo group (-2.50 ± 3.54 U/L vs. 3.80 ± 11.23 U/L, P = 0.006). TC (-13.04 ± 25.65 mg/dL, P = 0.020) and LDL-C (-10.33 ± 24.15 mg/dL, P = 0.047) levels reduced in the test group after 12 weeks. Although PLC, appears the possibility of improving liver function in excessive drinkers, however, a larger scale and long-term intervention study should be performed. |
| ArticleNumber | 104535 |
| Author | Lee, Hyo-Jung Jung, Ji Hoon Kim, Jieun Kim, Sung-Hoon Park, Ju Hyun Maeng, Sungho Bok, Min Kyung Lim, Hyunjung |
| Author_xml | – sequence: 1 givenname: Ju Hyun surname: Park fullname: Park, Ju Hyun organization: Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, South Korea – sequence: 2 givenname: Min Kyung surname: Bok fullname: Bok, Min Kyung organization: Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, South Korea – sequence: 3 givenname: Jieun surname: Kim fullname: Kim, Jieun organization: Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, South Korea – sequence: 4 givenname: Sungho surname: Maeng fullname: Maeng, Sungho organization: Department of Comprehensive Health Science, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, South Korea – sequence: 5 givenname: Sung-Hoon surname: Kim fullname: Kim, Sung-Hoon organization: College of Korean Medicine, Kyung Hee University, Seoul 02447, South Korea – sequence: 6 givenname: Ji Hoon surname: Jung fullname: Jung, Ji Hoon organization: College of Korean Medicine, Kyung Hee University, Seoul 02447, South Korea – sequence: 7 givenname: Hyo-Jung surname: Lee fullname: Lee, Hyo-Jung organization: College of Korean Medicine, Kyung Hee University, Seoul 02447, South Korea – sequence: 8 givenname: Hyunjung surname: Lim fullname: Lim, Hyunjung email: hjlim@khu.ac.kr organization: Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, South Korea |
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| CitedBy_id | crossref_primary_10_1016_j_lwt_2024_117055 crossref_primary_10_1016_j_biopha_2022_113501 |
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| Keywords | Fatty liver Alcohol use disorder P. koraiensis PLC Pinus koraiensis Nutritional supplement Alcoholic liver disease L. chinense S. chinensis (Lour.) Baill |
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•GGT significantly decreased in the women PLC group compared with the placebo group.•TC, LDL-C, and HDL-C significantly decreased in the PLC... Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves,... |
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| SubjectTerms | alcohol abuse Alcohol use disorder Alcoholic liver disease blood Fatty liver fruits lipids liver liver diseases liver function Lycium chinense Nutritional supplement Pinus koraiensis placebos risk factors Saururus chinensis |
| Title | Effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves on liver function in excessive drinkers: A randomized, double-blind, placebo-controlled trial |
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