Diffuse Glioma Heterogeneity and Its Therapeutic Implications

• Published in: Cancer discovery Vol. 11; no. 3; pp. 575 - 590
• Main Authors: Nicholson, James G., Fine, Howard A.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021
• Subjects: Animals; Biological Variation, Population; Biomarkers, Tumor; Clinical Decision-Making; Combined Modality Therapy; Disease Management; Disease Susceptibility; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Glioma - diagnosis; Glioma - etiology; Glioma - therapy; Humans; Neoplasm Grading; Neoplasm Staging; Prognosis; Treatment Outcome; Tumor Microenvironment

Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies. Recent advances have revealed that a remarkable level of genetic, epigenetic, and environmental heterogeneity exists within each individual glioma. Tog...