Caenorhabditis elegans as a Diagnostic Aid for Pancreatic Cancer

• Published in: Pancreas Vol. 50; no. 5; p. 673
• Main Authors: Kobayashi, Masanori, Fujita, Akashi, Ogawa, Tomoya, Tanisaka, Yuki, Mizuide, Masafumi, Kondo, Nobuaki, Imaizumi, Yuki, Hirotsu, Takaaki, Ryozawa, Shomei
• Format: Journal Article
• Language: English
• Published: United States 01.05.2021
• Subjects: Aged; Animals; Biological Assay; Biomarkers, Tumor - urine; Caenorhabditis elegans - physiology; Early Detection of Cancer; Female; Humans; Male; Middle Aged; Neoplasm Staging; Odorants - analysis; Olfactory Perception; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - urine; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Smell

Early detection of pancreatic cancer is notoriously difficult. A novel cancer diagnostic method using the ability of nematodes to detect odor of urine samples has been developed (N-NOSE). This method has a high sensitivity and specificity for various cancers; however, it has not yet been verified in...