The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

• Published in: Chemical Society reviews Vol. 52; no. 3; pp. 879 - 92
• Main Authors: Han, Hai-Hao, Wang, Han-Min, Jangili, Paramesh, Li, Mingle, Wu, Luling, Zang, Yi, Sedgwick, Adam C, Li, Jia, He, Xiao-Peng, James, Tony D, Kim, Jong Seung
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 06.02.2023
• Subjects: Biomarkers; Cancer; Cancer therapies; Drugs; Fluorescence; Humans; Magnetic resonance imaging; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Prodrugs - pharmacology; Prodrugs - therapeutic use; Selectivity; Tumor Microenvironment

Cancer remains as one of the most significant health problems, with approximately 19 million people diagnosed worldwide each year. Chemotherapy is a routinely used method to treat cancer patients. However, current treatment options lack the appropriate selectivity for cancer cells, are prone to resi...