Detecting human coronary inflammation by imaging perivascular fat

• Published in: Science translational medicine Vol. 9; no. 398
• Main Authors: Antonopoulos, Alexios S, Sanna, Fabio, Sabharwal, Nikant, Thomas, Sheena, Oikonomou, Evangelos K, Herdman, Laura, Margaritis, Marios, Shirodaria, Cheerag, Kampoli, Anna-Maria, Akoumianakis, Ioannis, Petrou, Mario, Sayeed, Rana, Krasopoulos, George, Psarros, Constantinos, Ciccone, Patricia, Brophy, Carl M, Digby, Janet, Kelion, Andrew, Uberoi, Raman, Anthony, Suzan, Alexopoulos, Nikolaos, Tousoulis, Dimitris, Achenbach, Stephan, Neubauer, Stefan, Channon, Keith M, Antoniades, Charalambos
• Format: Journal Article
• Language: English
• Published: United States 12.07.2017
• Subjects: Adipocytes - pathology; Adipogenesis; Adipose Tissue - blood supply; Adipose Tissue - pathology; Cell Differentiation; Cell Proliferation; Cell Size; Coronary Vessels - diagnostic imaging; Coronary Vessels - pathology; Cytokines - metabolism; Humans; Imaging, Three-Dimensional; Inflammation - diagnostic imaging; Inflammation - pathology; Lipids - chemistry; Phenotype; Plaque, Atherosclerotic - diagnostic imaging; Plaque, Atherosclerotic - pathology; Tomography, X-Ray Computed

Early detection of vascular inflammation would allow deployment of targeted strategies for the prevention or treatment of multiple disease states. Because vascular inflammation is not detectable with commonly used imaging modalities, we hypothesized that phenotypic changes in perivascular adipose ti...