Identification of α-glucosidase inhibitors from Mulberry using UF-UPLC-QTOF-MS/MS and molecular docking

• Published in: Journal of functional foods Vol. 101; p. 105362
• Main Authors: Abudurexiti, Adalaiti, Zhang, Rui, Zhong, Yewei, Tan, Huiwen, Yan, Junlin, Bake, Subinuer, Ma, Xiaoli
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.02.2023
• Subjects: acarbose; active sites; animals; food plants; glycemic effect; HepG2 cells; insulin resistance; Molecular docking; mulberries; Mulberry; noninsulin-dependent diabetes mellitus; Oriental traditional medicine; spectroscopy; therapeutics; UF-UPLC-QTOF-MS/MS; α-glucosidase inhibitor; Mulberry; HepG2 cells; α-glucosidase inhibitor; UF-UPLC-QTOF-MS/MS; Molecular docking

[Display omitted] •In this study, mulberry was used as a natural drug candidate for the screening of α-glucosidase inhibitory components of mulberry extracts by affinity ultrafiltration liquid mass spectrometry.•Molecular docking studies showed that these small molecules were more likely to occupy t...