The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine

Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected...

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Published inCancers Vol. 16; no. 18; p. 3129
Main Authors Nassar, Sami I, Suk, Amber, Nguyen, Shaun A, Adilbay, Dauren, Pang, John, Nathan, Cherie-Ann O
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.09.2024
MDPI
Subjects
Apoptosis
Biomarkers
Biopsy
Body fluids
Cancer
Cancer therapies
Cell death
Cellular biology
Development and progression
Diagnosis
Disease
Diseases
DNA methylation
Drug therapy
Exocrine glands
Head & neck cancer
Head and neck
Head and neck cancer
Health aspects
Human papillomavirus
Hypoxia
Larynx
Literature reviews
Medical prognosis
Metabolites
Metastasis
Methylation
National libraries
Oncology
Patients
Plasma
Precision medicine
Relapse
Review
RNA
Tumor cells
Tumors
United States > US
genetic mutations
nasopharyngeal carcinoma
head and neck cancer
genomic sequencing
cancer biomarkers
ctDNA
liquid biopsy
oropharyngeal carcinoma
squamous cell carcinoma
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Abstract Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. The monitoring of biomarkers for head and neck cancer via liquid biopsy, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.
AbstractList Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. The monitoring of biomarkers for head and neck cancer via liquid biopsy, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.
Simple SummaryLiquid biopsy’s use in the field of head and neck cancer has garnered interest due to providing an efficient and insightful alternative or complement to the present standards for the diagnosis and monitoring of patients. Certain biomarkers have been associated with specific cancer diagnoses, responses to treatment, and risk of recurrence, including circulating tumor DNA. Analysis of circulating tumor DNA and viral DNA via liquid biopsy has linked certain mutations and methylation patterns to various patient outcomes across several types of head and neck cancer. The present paper has reviewed the recent literature examining liquid biopsy’s clinical utility in head and neck oncology and has discussed the clinical implications of aspects of circulating tumor DNA, among other biomarkers.AbstractRecent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. The monitoring of biomarkers for head and neck cancer via liquid biopsy, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.
Liquid biopsy’s use in the field of head and neck cancer has garnered interest due to providing an efficient and insightful alternative or complement to the present standards for the diagnosis and monitoring of patients. Certain biomarkers have been associated with specific cancer diagnoses, responses to treatment, and risk of recurrence, including circulating tumor DNA. Analysis of circulating tumor DNA and viral DNA via liquid biopsy has linked certain mutations and methylation patterns to various patient outcomes across several types of head and neck cancer. The present paper has reviewed the recent literature examining liquid biopsy’s clinical utility in head and neck oncology and has discussed the clinical implications of aspects of circulating tumor DNA, among other biomarkers. Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. The monitoring of biomarkers for head and neck cancer via liquid biopsy, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.
Liquid biopsy’s use in the field of head and neck cancer has garnered interest due to providing an efficient and insightful alternative or complement to the present standards for the diagnosis and monitoring of patients. Certain biomarkers have been associated with specific cancer diagnoses, responses to treatment, and risk of recurrence, including circulating tumor DNA. Analysis of circulating tumor DNA and viral DNA via liquid biopsy has linked certain mutations and methylation patterns to various patient outcomes across several types of head and neck cancer. The present paper has reviewed the recent literature examining liquid biopsy’s clinical utility in head and neck oncology and has discussed the clinical implications of aspects of circulating tumor DNA, among other biomarkers.
Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. The monitoring of biomarkers for head and neck cancer via liquid biopsy, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. The monitoring of biomarkers for head and neck cancer via liquid biopsy, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.
Audience Academic
Author Nguyen, Shaun A
Adilbay, Dauren
Pang, John
Nathan, Cherie-Ann O
Nassar, Sami I
Suk, Amber
AuthorAffiliation 2 Department of Otolaryngology—Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA; amber.suk@lsuhs.edu (A.S.); john.pang@lsuhs.edu (J.P.)
1 Department of Otolaryngology—Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA; nassar@musc.edu (S.I.N.); nguyensh@musc.edu (S.A.N.); adilbay@musc.edu (D.A.)
AuthorAffiliation_xml – name: 2 Department of Otolaryngology—Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA; amber.suk@lsuhs.edu (A.S.); john.pang@lsuhs.edu (J.P.)
– name: 1 Department of Otolaryngology—Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA; nassar@musc.edu (S.I.N.); nguyensh@musc.edu (S.A.N.); adilbay@musc.edu (D.A.)
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  fullname: Nassar, Sami I
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– sequence: 2
  givenname: Amber
  surname: Suk
  fullname: Suk, Amber
  organization: Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
– sequence: 3
  givenname: Shaun A
  orcidid: 0000-0003-0664-4571
  surname: Nguyen
  fullname: Nguyen, Shaun A
  organization: Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
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  givenname: Dauren
  orcidid: 0000-0002-5555-2019
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  givenname: Cherie-Ann O
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  surname: Nathan
  fullname: Nathan, Cherie-Ann O
  organization: Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39335101$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1056/NEJMoa1701717
10.1093/annonc/mdx508.016
10.3389/fonc.2024.1374816
10.1007/s10555-017-9685-x
10.1016/j.jbiotec.2019.04.002
10.1158/1078-0432.CCR-19-0211
10.1186/s12859-019-2791-8
10.1172/jci.insight.177759
10.3390/ijms241713219
10.1038/s41431-018-0132-4
10.1186/s12885-016-2785-0
10.1016/j.ejca.2012.05.007
10.1016/j.oraloncology.2014.02.006
10.1080/0284186X.2020.1742930
10.1002/cncr.34823
10.1038/s41415-022-5166-x
10.3233/CBM-190160
10.1016/j.oraloncology.2022.105805
10.1177/1099800416642571
10.1002/ijc.34561
10.1038/s41598-023-45001-w
10.3389/fonc.2019.01510
10.1038/s41572-020-00224-3
10.21037/tcr.2019.12.70
10.1038/s41416-019-0575-6
10.1002/cam4.6191
10.1038/s41388-020-1327-z
10.1158/1078-0432.CCR-21-3151
10.1007/978-3-030-69852-2_5
10.1016/S0140-6736(19)30956-0
10.3322/caac.21834
10.1016/j.oraloncology.2017.09.012
10.1038/s41416-021-01626-0
10.1016/j.jdsr.2023.08.004
10.1016/j.mrrev.2023.108477
10.1038/s41571-020-00457-x
10.3389/fonc.2022.828434
10.1016/j.mayocp.2015.12.017
10.1002/ijc.33217
10.1002/ijc.29192
10.3390/cancers14051286
10.1017/erm.2017.12
10.1586/14737159.2016.1127758
10.1200/JCO.22.00264
10.1016/j.bj.2024.100748
10.1007/s11912-023-01365-w
10.1158/1078-0432.CCR-03-0139
10.1530/ERC-23-0002
10.3322/caac.21660
10.3390/cancers16071377
10.3390/biomedicines9111548
10.1002/cam4.1858
10.1073/pnas.1804184115
10.1016/j.tranon.2022.101507
10.1001/jamaoto.2014.1338
10.1158/0008-5472.CAN-18-3402
10.1007/s10555-024-10176-9
10.1210/clinem/dgac222
10.1200/EDBK_389718
10.3390/cancers14122858
10.3390/cancers13112725
10.1007/s00428-016-1905-1
10.1089/thy.2023.0204
10.3390/ijms241813767
10.1038/s41576-018-0071-5
10.1016/j.critrevonc.2020.103109
10.1038/nrc3066
10.1016/j.oraloncology.2016.07.014
10.1200/PO.18.00276
10.1128/spectrum.00024-24
10.1200/PO.23.00382
10.1007/978-3-030-22254-3_2
10.3390/cancers13163923
10.1373/clinchem.2017.285668
10.3748/wjg.v30.i15.2175
10.1016/j.microc.2022.107452
10.1093/annonc/mdy141
10.3390/ijms21218062
10.1186/s12967-020-02330-y
10.1016/j.bdq.2016.05.002
10.1016/j.radonc.2018.07.016
10.2217/bmm-2021-0370
10.1007/s00432-022-04350-1
10.1038/nature14129
10.1002/ohn.760
10.1080/00016489.2023.2238757
10.1002/cac2.12100
10.1186/s12916-022-02463-5
10.1186/s13045-022-01351-y
10.1158/2159-8290.CD-20-1311
10.1016/S0140-6736(21)01550-6
10.1186/1750-9378-6-4
10.1002/hed.23842
10.1016/j.canep.2013.05.012
10.1634/theoncologist.2018-0387
10.1002/hed.24372
10.1007/s11814-022-1348-0
10.1016/j.ijom.2020.11.012
10.1016/j.molmed.2010.07.001
10.1001/jamaoto.2023.1937
10.1038/s41390-022-02448-3
10.1016/j.cca.2020.01.013
10.1002/onco.13573
10.1371/journal.pone.0140712
10.1016/j.jlb.2024.100146
10.1158/2159-8290.CD-15-1483
10.1186/s40246-019-0220-8
10.1002/hed.25140
10.1093/annonc/mdy251
10.1089/thy.2016.0076
10.1002/jcp.29591
10.1111/eci.13015
10.1038/nrg3305
10.1007/s11673-019-09944-y
10.3390/cancers13081874
10.1001/jamaoto.2022.4107
10.3390/biom13091418
10.1200/JCO.2022.40.16_suppl.6097
10.1177/0022034518762071
10.1158/1078-0432.CCR-17-1181
10.1126/science.1206923
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Issue 18
Keywords genetic mutations
nasopharyngeal carcinoma
head and neck cancer
genomic sequencing
cancer biomarkers
ctDNA
liquid biopsy
oropharyngeal carcinoma
squamous cell carcinoma
Language English
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References ref_137
ref_136
ref_139
ref_91
ref_138
Yang (ref_30) 2015; 136
Santos (ref_46) 2022; 16
ref_14
Nicholls (ref_97) 2019; 121
Misawa (ref_25) 2020; 39
Ciampi (ref_45) 2022; 107
Ma (ref_119) 2015; 3
Xie (ref_127) 2023; 41
ref_133
Spector (ref_52) 2018; 25
ref_132
ref_135
ref_95
Liu (ref_99) 2024; 2024
ref_134
Tian (ref_29) 2013; 37
Mishra (ref_58) 2022; 126
Britze (ref_102) 2023; 143
Pannone (ref_73) 2011; 6
Ferrier (ref_85) 2023; 12
Schirmer (ref_115) 2018; 64
Bellairs (ref_17) 2017; 36
Mydlarz (ref_26) 2016; 38
Chan (ref_68) 2017; 377
Lawrence (ref_78) 2015; 517
Lee (ref_41) 2023; 40
Febbo (ref_131) 2024; 8
Lele (ref_61) 2024; 171
Wong (ref_31) 2004; 10
Haring (ref_126) 2023; 129
Huang (ref_22) 2023; 793
ref_24
ref_120
Pessoa (ref_18) 2020; 155
ref_121
Wilson (ref_23) 2021; 26
ref_123
Heitzer (ref_19) 2019; 20
Su (ref_92) 2024; 43
Tan (ref_32) 2020; 40
Zwirner (ref_117) 2018; 129
ref_27
Kim (ref_82) 2016; 38
(ref_36) 2019; 24
Lo (ref_93) 1999; 59
Payne (ref_75) 2018; 40
Sung (ref_4) 2021; 71
Schmidt (ref_50) 2016; 16
ref_77
Mody (ref_1) 2021; 398
Xu (ref_12) 2018; 48
ref_76
Zeyghami (ref_107) 2023; 30
Marur (ref_72) 2016; 91
Zheng (ref_98) 2023; 153
Szemes (ref_7) 2018; 26
Polina (ref_11) 2020; 503
Wu (ref_100) 2020; 27
ref_83
Cappelletti (ref_103) 2018; 29
Bigagli (ref_105) 2022; 25
ref_80
Economopoulou (ref_74) 2017; 74
Leon (ref_13) 1977; 37
Damerla (ref_67) 2019; 3
ref_140
ref_142
ref_141
Sandulache (ref_40) 2017; 27
ref_143
Mastoraki (ref_20) 2018; 24
Wei (ref_44) 2022; 179
Whale (ref_112) 2016; 10
Chen (ref_62) 2019; 13
Naegele (ref_87) 2023; 149
Araujo (ref_111) 2023; 25
Tarasova (ref_38) 2024; 34
Ahn (ref_69) 2014; 140
Heidrich (ref_124) 2021; 148
Pantel (ref_16) 2016; 6
ref_57
ref_56
Wei (ref_101) 2023; 149
Frank (ref_118) 2016; 18
Pantel (ref_47) 2010; 16
ref_53
Johnson (ref_71) 2020; 6
Mandel (ref_6) 1948; 142
ref_59
Spector (ref_9) 2023; 94
Nikanjam (ref_55) 2022; 15
Pantel (ref_49) 2021; 11
Ferrandino (ref_63) 2023; 149
Jakimovska (ref_54) 2024; 2024
Fisher (ref_104) 2021; 50
Schwarzenbach (ref_48) 2011; 11
Buglione (ref_106) 2012; 48
Porter (ref_108) 2020; 9
Schmidt (ref_51) 2016; 61
Hanna (ref_84) 2018; 29
Pall (ref_28) 2020; 59
Chera (ref_66) 2019; 25
Hanna (ref_128) 2023; 43
Gormley (ref_3) 2022; 233
Chen (ref_89) 2019; 394
Metcalf (ref_35) 2017; 28
ref_114
Jahr (ref_15) 2001; 61
ref_116
Ignatiadis (ref_130) 2021; 18
Lam (ref_96) 2018; 115
Mannelli (ref_129) 2019; 16
ref_33
Liu (ref_125) 2024; 30
(ref_21) 2019; 297
Agrawal (ref_79) 2011; 333
Nonaka (ref_110) 2018; 97
Siravegna (ref_65) 2022; 28
Alves (ref_88) 2022; 3
Peng (ref_94) 2018; 7
ref_39
Rutkowski (ref_60) 2020; 18
ref_37
Khatami (ref_43) 2020; 235
Brauswetter (ref_81) 2016; 468
Tsao (ref_90) 2014; 50
(ref_70) 2023; 59
Bhambhani (ref_86) 2024; 9
ref_109
Rossi (ref_122) 2019; 79
Nekrutenko (ref_113) 2012; 13
Bray (ref_5) 2024; 74
ref_42
Celec (ref_10) 2018; 20
ref_2
Mattox (ref_64) 2022; 128
ref_8
Russell (ref_34) 2022; 40
References_xml – volume: 377
  start-page: 513
  year: 2017
  ident: ref_68
  article-title: Analysis of plasma Epstein–Barr virus DNA to screen for nasopharyngeal cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1701717
  contributor:
    fullname: Chan
– volume: 28
  start-page: vii8
  year: 2017
  ident: ref_35
  article-title: The application of liquid biopsies in metastatic salivary gland cancer to identify candidate therapeutic targets
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdx508.016
  contributor:
    fullname: Metcalf
– ident: ref_76
  doi: 10.3389/fonc.2024.1374816
– volume: 36
  start-page: 515
  year: 2017
  ident: ref_17
  article-title: Tumor DNA: An emerging biomarker in head and neck cancer
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-017-9685-x
  contributor:
    fullname: Bellairs
– volume: 297
  start-page: 66
  year: 2019
  ident: ref_21
  article-title: Liquid biopsy for predictive mutational profiling of solid cancer: The pathologist’s perspective
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2019.04.002
– volume: 25
  start-page: 4682
  year: 2019
  ident: ref_66
  article-title: Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-19-0211
  contributor:
    fullname: Chera
– ident: ref_114
  doi: 10.1186/s12859-019-2791-8
– volume: 9
  start-page: e177759
  year: 2024
  ident: ref_86
  article-title: ctDNA transiting into urine is ultrashort and facilitates noninvasive liquid biopsy of HPV+ oropharyngeal cancer
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.177759
  contributor:
    fullname: Bhambhani
– ident: ref_14
  doi: 10.3390/ijms241713219
– volume: 26
  start-page: 937
  year: 2018
  ident: ref_7
  article-title: Circulating cell-free nucleic acids: Characteristics and applications
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/s41431-018-0132-4
  contributor:
    fullname: Szemes
– ident: ref_27
  doi: 10.1186/s12885-016-2785-0
– ident: ref_132
– volume: 48
  start-page: 3019
  year: 2012
  ident: ref_106
  article-title: Circulating tumour cells in locally advanced head and neck cancer: Preliminary report about their possible role in predicting response to non-surgical treatment and survival
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2012.05.007
  contributor:
    fullname: Buglione
– volume: 50
  start-page: 330
  year: 2014
  ident: ref_90
  article-title: Etiological factors of nasopharyngeal carcinoma
  publication-title: Oral Oncol.
  doi: 10.1016/j.oraloncology.2014.02.006
  contributor:
    fullname: Tsao
– volume: 37
  start-page: 646
  year: 1977
  ident: ref_13
  article-title: Free DNA in the serum of cancer patients and the effect of therapy
  publication-title: Cancer Res.
  contributor:
    fullname: Leon
– volume: 59
  start-page: 845
  year: 2020
  ident: ref_28
  article-title: Circulating tumour DNA alterations as biomarkers for head and neck cancer: A systematic review
  publication-title: Acta Oncol.
  doi: 10.1080/0284186X.2020.1742930
  contributor:
    fullname: Pall
– volume: 129
  start-page: 2817
  year: 2023
  ident: ref_126
  article-title: Patterns of recurrence in head and neck squamous cell carcinoma to inform personalized surveillance protocols
  publication-title: Cancer
  doi: 10.1002/cncr.34823
  contributor:
    fullname: Haring
– volume: 233
  start-page: 780
  year: 2022
  ident: ref_3
  article-title: Reviewing the epidemiology of head and neck cancer: Definitions, trends and risk factors
  publication-title: Br. Dent. J.
  doi: 10.1038/s41415-022-5166-x
  contributor:
    fullname: Gormley
– volume: 27
  start-page: 365
  year: 2020
  ident: ref_100
  article-title: Circulating Epstein-Barr virus microRNA profile reveals novel biomarker for nasopharyngeal carcinoma diagnosis
  publication-title: Cancer Biomark.
  doi: 10.3233/CBM-190160
  contributor:
    fullname: Wu
– volume: 128
  start-page: 105805
  year: 2022
  ident: ref_64
  article-title: Comparison of next generation sequencing, droplet digital PCR, and quantitative real-time PCR for the earlier detection and quantification of HPV in HPV-positive oropharyngeal cancer
  publication-title: Oral Oncol.
  doi: 10.1016/j.oraloncology.2022.105805
  contributor:
    fullname: Mattox
– volume: 18
  start-page: 477
  year: 2016
  ident: ref_118
  article-title: Circulating cell-free DNA differentiates severity of inflammation
  publication-title: Biol. Res. Nurs.
  doi: 10.1177/1099800416642571
  contributor:
    fullname: Frank
– volume: 153
  start-page: 882
  year: 2023
  ident: ref_98
  article-title: Saliva biopsy: Detecting the difference of EBV DNA methylation in the diagnosis of nasopharyngeal carcinoma
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.34561
  contributor:
    fullname: Zheng
– ident: ref_141
– ident: ref_33
  doi: 10.1038/s41598-023-45001-w
– ident: ref_42
  doi: 10.3389/fonc.2019.01510
– ident: ref_135
– volume: 6
  start-page: 92
  year: 2020
  ident: ref_71
  article-title: Head and neck squamous cell carcinoma
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-020-00224-3
  contributor:
    fullname: Johnson
– volume: 9
  start-page: 203
  year: 2020
  ident: ref_108
  article-title: Next generation sequencing of cell free circulating tumor DNA in blood samples of recurrent and metastatic head and neck cancer patients
  publication-title: Transl. Cancer Res.
  doi: 10.21037/tcr.2019.12.70
  contributor:
    fullname: Porter
– volume: 121
  start-page: 690
  year: 2019
  ident: ref_97
  article-title: Negative plasma Epstein-Barr virus DNA nasopharyngeal carcinoma in an endemic region and its influence on liquid biopsy screening programmes
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-019-0575-6
  contributor:
    fullname: Nicholls
– volume: 12
  start-page: 15777
  year: 2023
  ident: ref_85
  article-title: Blood and saliva-derived ctDNA is a marker of residual disease after treatment and correlates with recurrence in human papillomavirus-associated head and neck cancer
  publication-title: Cancer Med.
  doi: 10.1002/cam4.6191
  contributor:
    fullname: Ferrier
– volume: 39
  start-page: 4741
  year: 2020
  ident: ref_25
  article-title: Identification of novel methylation markers in HPV-associated oropharyngeal cancer: Genome-wide discovery, tissue verification and validation testing in ctDNA
  publication-title: Oncogene
  doi: 10.1038/s41388-020-1327-z
  contributor:
    fullname: Misawa
– volume: 28
  start-page: 719
  year: 2022
  ident: ref_65
  article-title: Cell-free HPV DNA provides an accurate and rapid diagnosis of HPV-associated head and neck cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-21-3151
  contributor:
    fullname: Siravegna
– ident: ref_80
  doi: 10.1007/978-3-030-69852-2_5
– volume: 394
  start-page: 64
  year: 2019
  ident: ref_89
  article-title: Nasopharyngeal carcinoma
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)30956-0
  contributor:
    fullname: Chen
– volume: 74
  start-page: 229
  year: 2024
  ident: ref_5
  article-title: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA A Cancer J. Clin.
  doi: 10.3322/caac.21834
  contributor:
    fullname: Bray
– volume: 74
  start-page: 83
  year: 2017
  ident: ref_74
  article-title: Liquid biopsy: An emerging prognostic and predictive tool in head and neck squamous cell carcinoma (HNSCC). Focus on circulating tumor cells (CTCs)
  publication-title: Oral Oncol.
  doi: 10.1016/j.oraloncology.2017.09.012
  contributor:
    fullname: Economopoulou
– volume: 126
  start-page: 361
  year: 2022
  ident: ref_58
  article-title: Application of liquid biopsy as multi-functional biomarkers in head and neck cancer
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-021-01626-0
  contributor:
    fullname: Mishra
– ident: ref_140
– volume: 59
  start-page: 289
  year: 2023
  ident: ref_70
  article-title: Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer
  publication-title: Jpn. Dent. Sci. Rev.
  doi: 10.1016/j.jdsr.2023.08.004
– ident: ref_134
– volume: 793
  start-page: 108477
  year: 2023
  ident: ref_22
  article-title: A comparison between mutational profiles in tumour tissue DNA and circulating tumour DNA in head and neck squamous cell carcinoma—A systematic review
  publication-title: Mutat. Res. Rev. Mutat. Res.
  doi: 10.1016/j.mrrev.2023.108477
  contributor:
    fullname: Huang
– volume: 18
  start-page: 297
  year: 2021
  ident: ref_130
  article-title: Liquid biopsy enters the clinic—Implementation issues and future challenges
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/s41571-020-00457-x
  contributor:
    fullname: Ignatiadis
– ident: ref_57
  doi: 10.3389/fonc.2022.828434
– volume: 91
  start-page: 386
  year: 2016
  ident: ref_72
  article-title: Head and neck squamous cell carcinoma: Update on epidemiology, diagnosis, and treatment
  publication-title: Mayo Clin. Proc.
  doi: 10.1016/j.mayocp.2015.12.017
  contributor:
    fullname: Marur
– volume: 25
  start-page: 251
  year: 2018
  ident: ref_52
  article-title: The potential for liquid biopsies in head and neck cancer
  publication-title: Discov. Med.
  contributor:
    fullname: Spector
– volume: 148
  start-page: 528
  year: 2021
  ident: ref_124
  article-title: Liquid biopsies: Potential and challenges
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.33217
  contributor:
    fullname: Heidrich
– volume: 136
  start-page: E127
  year: 2015
  ident: ref_30
  article-title: Epigenetic markers for noninvasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.29192
  contributor:
    fullname: Yang
– ident: ref_83
  doi: 10.3390/cancers14051286
– volume: 59
  start-page: 1188
  year: 1999
  ident: ref_93
  article-title: Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma
  publication-title: Cancer Res.
  contributor:
    fullname: Lo
– volume: 20
  start-page: e1
  year: 2018
  ident: ref_10
  article-title: Cell-free DNA: The role in pathophysiology and as a biomarker in kidney diseases
  publication-title: Expert Rev. Mol. Med.
  doi: 10.1017/erm.2017.12
  contributor:
    fullname: Celec
– volume: 16
  start-page: 165
  year: 2016
  ident: ref_50
  article-title: A liquid biopsy for head and neck cancers
  publication-title: Expert Rev. Mol. Diagn.
  doi: 10.1586/14737159.2016.1127758
  contributor:
    fullname: Schmidt
– volume: 41
  start-page: 2483
  year: 2023
  ident: ref_127
  article-title: Clinical uncertainties of circulating tumor DNA in human papillomavirus–related oropharyngeal squamous cell carcinoma in the absence of National Comprehensive Cancer Network Guidelines
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.22.00264
  contributor:
    fullname: Xie
– ident: ref_53
  doi: 10.1016/j.bj.2024.100748
– volume: 25
  start-page: 279
  year: 2023
  ident: ref_111
  article-title: Diagnostic accuracy of liquid biopsy for Oral potentially malignant disorders and head and neck cancer: An overview of systematic reviews
  publication-title: Curr. Oncol. Rep.
  doi: 10.1007/s11912-023-01365-w
  contributor:
    fullname: Araujo
– volume: 10
  start-page: 2401
  year: 2004
  ident: ref_31
  article-title: Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-03-0139
  contributor:
    fullname: Wong
– volume: 30
  start-page: e230002
  year: 2023
  ident: ref_107
  article-title: Liquid biopsies in thyroid cancers: A systematic review and meta-analysis
  publication-title: Endocr. Relat. Cancer
  doi: 10.1530/ERC-23-0002
  contributor:
    fullname: Zeyghami
– volume: 71
  start-page: 209
  year: 2021
  ident: ref_4
  article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA A Cancer J. Clin.
  doi: 10.3322/caac.21660
  contributor:
    fullname: Sung
– ident: ref_143
– ident: ref_121
  doi: 10.3390/cancers16071377
– ident: ref_77
  doi: 10.3390/biomedicines9111548
– volume: 7
  start-page: 5988
  year: 2018
  ident: ref_94
  article-title: Relationship between pretreatment concentration of plasma Epstein-Barr virus DNA and tumor burden in nasopharyngeal carcinoma: An updated interpretation
  publication-title: Cancer Med.
  doi: 10.1002/cam4.1858
  contributor:
    fullname: Peng
– volume: 115
  start-page: E5115
  year: 2018
  ident: ref_96
  article-title: Sequencing-based counting and size profiling of plasma Epstein–Barr virus DNA enhance population screening of nasopharyngeal carcinoma
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1804184115
  contributor:
    fullname: Lam
– ident: ref_137
– volume: 25
  start-page: 101507
  year: 2022
  ident: ref_105
  article-title: Low levels of miR-34c in nasal washings as a candidate marker of aggressive disease in wood and leather exposed workers with sinonasal intestinal-type adenocarcinomas (ITACs)
  publication-title: Transl. Oncol.
  doi: 10.1016/j.tranon.2022.101507
  contributor:
    fullname: Bigagli
– volume: 140
  start-page: 846
  year: 2014
  ident: ref_69
  article-title: Saliva and plasma quantitative polymerase chain reaction–based detection and surveillance of human papillomavirus–related head and neck cancer
  publication-title: JAMA Otolaryngol.-Head Neck Surg.
  doi: 10.1001/jamaoto.2014.1338
  contributor:
    fullname: Ahn
– volume: 79
  start-page: 2798
  year: 2019
  ident: ref_122
  article-title: Promises and pitfalls of using liquid biopsy for precision medicine
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-18-3402
  contributor:
    fullname: Rossi
– volume: 43
  start-page: 919
  year: 2024
  ident: ref_92
  article-title: Epidemiology of nasopharyngeal carcinoma: Current insights and future outlook
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-024-10176-9
  contributor:
    fullname: Su
– volume: 107
  start-page: e3420
  year: 2022
  ident: ref_45
  article-title: Pre-and post-operative circulating tumoral DNA in patients with medullary thyroid carcinoma
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/clinem/dgac222
  contributor:
    fullname: Ciampi
– volume: 43
  start-page: e389718
  year: 2023
  ident: ref_128
  article-title: Personalizing surveillance in head and neck cancer
  publication-title: Am. Soc. Clin. Oncol. Educ. Book
  doi: 10.1200/EDBK_389718
  contributor:
    fullname: Hanna
– volume: 61
  start-page: 1659
  year: 2001
  ident: ref_15
  article-title: DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells
  publication-title: Cancer Res.
  contributor:
    fullname: Jahr
– ident: ref_59
  doi: 10.3390/cancers14122858
– ident: ref_37
  doi: 10.3390/cancers13112725
– volume: 468
  start-page: 579
  year: 2016
  ident: ref_81
  article-title: Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma
  publication-title: Virchows Arch.
  doi: 10.1007/s00428-016-1905-1
  contributor:
    fullname: Brauswetter
– volume: 34
  start-page: 197
  year: 2024
  ident: ref_38
  article-title: Characterization of the Thyroid Cancer Genomic Landscape by Plasma-Based Circulating Tumor DNA Next-Generation Sequencing
  publication-title: Thyroid
  doi: 10.1089/thy.2023.0204
  contributor:
    fullname: Tarasova
– ident: ref_142
– ident: ref_39
  doi: 10.3390/ijms241813767
– volume: 20
  start-page: 71
  year: 2019
  ident: ref_19
  article-title: Current and future perspectives of liquid biopsies in genomics-driven oncology
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-018-0071-5
  contributor:
    fullname: Heitzer
– volume: 155
  start-page: 103109
  year: 2020
  ident: ref_18
  article-title: ctDNA as a cancer biomarker: A broad overview
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2020.103109
  contributor:
    fullname: Pessoa
– volume: 11
  start-page: 426
  year: 2011
  ident: ref_48
  article-title: Cell-free nucleic acids as biomarkers in cancer patients
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3066
  contributor:
    fullname: Schwarzenbach
– volume: 61
  start-page: 8
  year: 2016
  ident: ref_51
  article-title: The development of a liquid biopsy for head and neck cancers
  publication-title: Oral Oncol.
  doi: 10.1016/j.oraloncology.2016.07.014
  contributor:
    fullname: Schmidt
– volume: 3
  start-page: 1
  year: 2019
  ident: ref_67
  article-title: Detection of early human papillomavirus–associated cancers by liquid biopsy
  publication-title: JCO Precis. Oncol.
  doi: 10.1200/PO.18.00276
  contributor:
    fullname: Damerla
– ident: ref_116
  doi: 10.1128/spectrum.00024-24
– ident: ref_136
– volume: 8
  start-page: e2300382
  year: 2024
  ident: ref_131
  article-title: Recommendations for the equitable and widespread implementation of liquid biopsy for cancer care
  publication-title: JCO Precis. Oncol.
  doi: 10.1200/PO.23.00382
  contributor:
    fullname: Febbo
– volume: 142
  start-page: 241
  year: 1948
  ident: ref_6
  article-title: Nucleic acids of human blood plasma
  publication-title: Comptes Rendus Seances Soc. Biol. Ses Fil.
  contributor:
    fullname: Mandel
– ident: ref_91
  doi: 10.1007/978-3-030-22254-3_2
– ident: ref_120
  doi: 10.3390/cancers13163923
– volume: 2024
  start-page: 1
  year: 2024
  ident: ref_54
  article-title: Nasal Cavity and Paranasal Sinus Cancer: Diagnosis and Treatment
  publication-title: Curr. Oncol. Rep.
  contributor:
    fullname: Jakimovska
– volume: 64
  start-page: 959
  year: 2018
  ident: ref_115
  article-title: Cell-free plasma DNA for disease stratification and prognosis in head and neck cancer
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2017.285668
  contributor:
    fullname: Schirmer
– ident: ref_139
– volume: 30
  start-page: 2175
  year: 2024
  ident: ref_125
  article-title: Circulating tumor DNA in liquid biopsy: Current diagnostic limitation
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v30.i15.2175
  contributor:
    fullname: Liu
– volume: 3
  start-page: 533
  year: 2022
  ident: ref_88
  article-title: Clinical applications of liquid biopsy in HPV-negative and HPV-positive head and neck squamous cell carcinoma: Advances and challenges
  publication-title: Explor. Target. Anti-Tumor Ther.
  contributor:
    fullname: Alves
– volume: 179
  start-page: 107452
  year: 2022
  ident: ref_44
  article-title: Detection of BRAFV600E mutation of thyroid cancer in circulating tumor DNA by an electrochemical-enrichment assisted ARMS-qPCR assay
  publication-title: Microchem. J.
  doi: 10.1016/j.microc.2022.107452
  contributor:
    fullname: Wei
– volume: 29
  start-page: 1599
  year: 2018
  ident: ref_103
  article-title: Tailoring treatment of salivary duct carcinoma (SDC) by liquid biopsy: ARv7 expression in circulating tumor cells
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdy141
  contributor:
    fullname: Cappelletti
– ident: ref_8
  doi: 10.3390/ijms21218062
– volume: 18
  start-page: 167
  year: 2020
  ident: ref_60
  article-title: Circulating HPV16 DNA may complement imaging assessment of early treatment efficacy in patients with HPV-positive oropharyngeal cancer
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-020-02330-y
  contributor:
    fullname: Rutkowski
– volume: 10
  start-page: 15
  year: 2016
  ident: ref_112
  article-title: Fundamentals of multiplexing with digital PCR
  publication-title: Biomol. Detect. Quantif.
  doi: 10.1016/j.bdq.2016.05.002
  contributor:
    fullname: Whale
– volume: 129
  start-page: 575
  year: 2018
  ident: ref_117
  article-title: Circulating cell-free DNA: A potential biomarker to differentiate inflammation and infection during radiochemotherapy
  publication-title: Radiother. Oncol.
  doi: 10.1016/j.radonc.2018.07.016
  contributor:
    fullname: Zwirner
– volume: 16
  start-page: 127
  year: 2022
  ident: ref_46
  article-title: Liquid biopsy: The value of different bodily fluids
  publication-title: Biomark. Med.
  doi: 10.2217/bmm-2021-0370
  contributor:
    fullname: Santos
– volume: 149
  start-page: 4403
  year: 2023
  ident: ref_101
  article-title: Down-regulated lncRNA ROR in tumor-educated platelets as a liquid-biopsy biomarker for nasopharyngeal carcinoma
  publication-title: J. Cancer Res. Clin. Oncol.
  doi: 10.1007/s00432-022-04350-1
  contributor:
    fullname: Wei
– volume: 517
  start-page: 576
  year: 2015
  ident: ref_78
  article-title: Comprehensive genomic characterization of head and neck squamous cell carcinomas
  publication-title: Nature
  doi: 10.1038/nature14129
  contributor:
    fullname: Lawrence
– volume: 171
  start-page: 439
  year: 2024
  ident: ref_61
  article-title: ctDNA as an Adjunct to Posttreatment PET for Head and Neck Cancer Recurrence Risk
  publication-title: JAMA Otolaryngol.-Head Neck Surg.
  doi: 10.1002/ohn.760
  contributor:
    fullname: Lele
– volume: 143
  start-page: 709
  year: 2023
  ident: ref_102
  article-title: A systematic review on the role of biomarkers in liquid biopsies and saliva samples in the monitoring of salivary gland cancer
  publication-title: Acta Oto-Laryngol.
  doi: 10.1080/00016489.2023.2238757
  contributor:
    fullname: Britze
– volume: 2024
  start-page: 1
  year: 2024
  ident: ref_99
  article-title: Circulating tumor cells: A valuable indicator for locally advanced nasopharyngeal carcinoma
  publication-title: Eur. Arch. Oto-Rhino-Laryngol.
  contributor:
    fullname: Liu
– volume: 40
  start-page: 564
  year: 2020
  ident: ref_32
  article-title: Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma
  publication-title: Cancer Commun.
  doi: 10.1002/cac2.12100
  contributor:
    fullname: Tan
– ident: ref_95
  doi: 10.1186/s12916-022-02463-5
– volume: 15
  start-page: 131
  year: 2022
  ident: ref_55
  article-title: Liquid biopsy: Current technology and clinical applications
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-022-01351-y
  contributor:
    fullname: Nikanjam
– volume: 11
  start-page: 858
  year: 2021
  ident: ref_49
  article-title: Liquid biopsy: From discovery to clinical application
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-20-1311
  contributor:
    fullname: Pantel
– volume: 398
  start-page: 2289
  year: 2021
  ident: ref_1
  article-title: Head and neck cancer
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)01550-6
  contributor:
    fullname: Mody
– volume: 6
  start-page: 4
  year: 2011
  ident: ref_73
  article-title: The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: An overview
  publication-title: Infect. Agents Cancer
  doi: 10.1186/1750-9378-6-4
  contributor:
    fullname: Pannone
– volume: 38
  start-page: 9
  year: 2016
  ident: ref_26
  article-title: Serum biomarkers for detection of head and neck squamous cell carcinoma
  publication-title: Head Neck
  doi: 10.1002/hed.23842
  contributor:
    fullname: Mydlarz
– volume: 37
  start-page: 708
  year: 2013
  ident: ref_29
  article-title: Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma
  publication-title: Cancer Epidemiol.
  doi: 10.1016/j.canep.2013.05.012
  contributor:
    fullname: Tian
– volume: 24
  start-page: 293
  year: 2019
  ident: ref_36
  article-title: Nasoethmoidal intestinal-type adenocarcinoma treated with cetuximab: Role of liquid biopsy and BEAMing in predicting response to anti-epidermal growth factor receptor therapy
  publication-title: Oncologist
  doi: 10.1634/theoncologist.2018-0387
– volume: 38
  start-page: E2021
  year: 2016
  ident: ref_82
  article-title: Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma
  publication-title: Head Neck
  doi: 10.1002/hed.24372
  contributor:
    fullname: Kim
– volume: 3
  start-page: 235
  year: 2015
  ident: ref_119
  article-title: “Liquid biopsy”-ctDNA detection with great potential and challenges
  publication-title: Ann. Transl. Med.
  contributor:
    fullname: Ma
– volume: 40
  start-page: 429
  year: 2023
  ident: ref_41
  article-title: A high-sensitivity cfDNA capture enables to detect the BRAF V600E mutation in papillary thyroid carcinoma
  publication-title: Korean J. Chem. Eng.
  doi: 10.1007/s11814-022-1348-0
  contributor:
    fullname: Lee
– ident: ref_138
– volume: 50
  start-page: 994
  year: 2021
  ident: ref_104
  article-title: A pilot study for presence of circulating tumour cells in adenoid cystic carcinoma
  publication-title: Int. J. Oral Maxillofac. Surg.
  doi: 10.1016/j.ijom.2020.11.012
  contributor:
    fullname: Fisher
– volume: 16
  start-page: 398
  year: 2010
  ident: ref_47
  article-title: Circulating tumour cells in cancer patients: Challenges and perspectives
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2010.07.001
  contributor:
    fullname: Pantel
– volume: 149
  start-page: 971
  year: 2023
  ident: ref_63
  article-title: Performance of Liquid Biopsy for Diagnosis and Surveillance of Human Papillomavirus-Associated Oropharyngeal Cancer
  publication-title: JAMA Otolaryngol.-Head Neck Surg.
  doi: 10.1001/jamaoto.2023.1937
  contributor:
    fullname: Ferrandino
– volume: 94
  start-page: 89
  year: 2023
  ident: ref_9
  article-title: The methylome and cell-free DNA: Current applications in medicine and pediatric disease
  publication-title: Pediatr. Res.
  doi: 10.1038/s41390-022-02448-3
  contributor:
    fullname: Spector
– volume: 503
  start-page: 145
  year: 2020
  ident: ref_11
  article-title: Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2020.01.013
  contributor:
    fullname: Polina
– volume: 26
  start-page: e279
  year: 2021
  ident: ref_23
  article-title: The prognostic and therapeutic value of the mutational profile of blood and tumor tissue in head and neck squamous cell carcinoma
  publication-title: Oncologist
  doi: 10.1002/onco.13573
  contributor:
    fullname: Wilson
– ident: ref_109
  doi: 10.1371/journal.pone.0140712
– ident: ref_123
  doi: 10.1016/j.jlb.2024.100146
– volume: 6
  start-page: 479
  year: 2016
  ident: ref_16
  article-title: Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-15-1483
  contributor:
    fullname: Pantel
– volume: 13
  start-page: 34
  year: 2019
  ident: ref_62
  article-title: Next-generation sequencing in liquid biopsy: Cancer screening and early detection
  publication-title: Hum. Genom.
  doi: 10.1186/s40246-019-0220-8
  contributor:
    fullname: Chen
– volume: 40
  start-page: 1598
  year: 2018
  ident: ref_75
  article-title: Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma
  publication-title: Head Neck
  doi: 10.1002/hed.25140
  contributor:
    fullname: Payne
– ident: ref_2
– volume: 29
  start-page: 1980
  year: 2018
  ident: ref_84
  article-title: Plasma HPV cell-free DNA monitoring in advanced HPV-associated oropharyngeal cancer
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdy251
  contributor:
    fullname: Hanna
– volume: 27
  start-page: 81
  year: 2017
  ident: ref_40
  article-title: Real-time genomic characterization utilizing circulating cell-free DNA in patients with anaplastic thyroid carcinoma
  publication-title: Thyroid
  doi: 10.1089/thy.2016.0076
  contributor:
    fullname: Sandulache
– volume: 235
  start-page: 6954
  year: 2020
  ident: ref_43
  article-title: Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.29591
  contributor:
    fullname: Khatami
– volume: 48
  start-page: e13015
  year: 2018
  ident: ref_12
  article-title: High levels of circulating cell-free DNA are a biomarker of active SLE
  publication-title: Eur. J. Clin. Investig.
  doi: 10.1111/eci.13015
  contributor:
    fullname: Xu
– volume: 13
  start-page: 667
  year: 2012
  ident: ref_113
  article-title: Next-generation sequencing data interpretation: Enhancing reproducibility and accessibility
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3305
  contributor:
    fullname: Nekrutenko
– volume: 16
  start-page: 551
  year: 2019
  ident: ref_129
  article-title: Tissue vs. liquid biopsies for cancer detection: Ethical issues
  publication-title: J. Bioethical Inq.
  doi: 10.1007/s11673-019-09944-y
  contributor:
    fullname: Mannelli
– ident: ref_56
  doi: 10.3390/cancers13081874
– volume: 149
  start-page: 179
  year: 2023
  ident: ref_87
  article-title: Detection and monitoring of circulating tumor HPV DNA in HPV-associated sinonasal and nasopharyngeal cancers
  publication-title: JAMA Otolaryngol.-Head Neck Surg.
  doi: 10.1001/jamaoto.2022.4107
  contributor:
    fullname: Naegele
– ident: ref_133
– ident: ref_24
  doi: 10.3390/biom13091418
– volume: 40
  start-page: 6097
  year: 2022
  ident: ref_34
  article-title: Circulating tumor DNA profiling and serial analysis in salivary gland carcinomas reveal unique mutational subsets and actionable alterations
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2022.40.16_suppl.6097
  contributor:
    fullname: Russell
– volume: 97
  start-page: 701
  year: 2018
  ident: ref_110
  article-title: Liquid biopsy in head and neck cancer: Promises and challenges
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034518762071
  contributor:
    fullname: Nonaka
– volume: 24
  start-page: 1500
  year: 2018
  ident: ref_20
  article-title: ESR1 methylation: A liquid biopsy–based epigenetic assay for the follow-up of patients with metastatic breast cancer receiving endocrine treatment
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-17-1181
  contributor:
    fullname: Mastoraki
– volume: 333
  start-page: 1154
  year: 2011
  ident: ref_79
  article-title: Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
  publication-title: Science
  doi: 10.1126/science.1206923
  contributor:
    fullname: Agrawal
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Snippet Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and...
Liquid biopsy’s use in the field of head and neck cancer has garnered interest due to providing an efficient and insightful alternative or complement to the...
Simple SummaryLiquid biopsy’s use in the field of head and neck cancer has garnered interest due to providing an efficient and insightful alternative or...
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SubjectTerms Apoptosis
Biomarkers
Biopsy
Body fluids
Cancer
Cancer therapies
Cell death
Cellular biology
Development and progression
Diagnosis
Disease
Diseases
DNA methylation
Drug therapy
Exocrine glands
Head & neck cancer
Head and neck
Head and neck cancer
Health aspects
Human papillomavirus
Hypoxia
Larynx
Literature reviews
Medical prognosis
Metabolites
Metastasis
Methylation
National libraries
Oncology
Patients
Plasma
Precision medicine
Relapse
Review
RNA
Tumor cells
Tumors
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Title The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine
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Volume 16
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