Maternal embryonic leucine zipper kinase (MELK) optimally regulates the HIV-1 uncoating process

• Published in: Journal of theoretical biology Vol. 545; p. 111152
• Main Authors: Nishiyama, Takara, Takada, Toru, Takeuchi, Hiroaki, Iwami, Shingo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21.07.2022
• Subjects: HIV-1; HIV-1 capsid; Mathematical model; Uncoating; Virus dynamics; HIV-1; Uncoating; Virus dynamics; Mathematical model; HIV-1 capsid

•Modeling the process of core structure uncoating by MELK.•Quantifying the uncoating process in HIV-1 cDNA synthesis and nuclear trafficking.•In silico simulation results show that MELK optimally regulates the HIV-1 uncoating process. Human immunodeficiency virus type-1 (HIV-1) attaches to target ce...