Synthesis of optically active bisdifluorocyclopropanes through a chemo-enzymatic reaction strategy

• Published in: Tetrahedron letters Vol. 40; no. 31; pp. 5739 - 5742
• Main Authors: Mitsukura, Koichi, Korekiyo, Satoshi, Itoh, Toshiyuki
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 30.07.1999; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; 1,3-DIENES

The first synthesis of bisdifluorocyclopropane derivatives has been accomplished via a chemo-enzymatic reaction strategy; ( E)- or ( Z)-3-tributylstannyl-2-propenols were prepared and their conversion led to the ( trans,trans)- and ( cis,cis)-bisdifluorocyclopropanes. The subsequent lipase-catalyzed...