Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation - Miller, Rachael; Paquette, Joseph; Barker, Alexandra; Sapp, Ellen; McHugh, Nicholas; Bramato, Brianna; Yamada, Nozomi; Alterman, Julia; Echeveria, Dimas; Yamada, Ken; Watts, Jonathan; Anaclet, Christelle; et al. (Molecular therapy. Nucleic acids, 2024)
Keywords: brain delivery; CNS therapeutics; genetic diseases; Huntington’s disease; MT: Oligonucleotides: Therapies and Applications; neurological disorders; oligonucleotide-based therapies; oligonucleotides; RNAi; genetic diseases; brain delivery; MT: Oligonucleotides: Therapies and Applications; RNAi; neurological disorders; CNS therapeutics; Huntington’s disease; oligonucleotides; oligonucleotide-based therapies