Production of β-Chemokines in Human Immunodeficiency Virus (HIV) Infection: Evidence that High Levels of Macrophage Inflammatory Protein-1β Are Associated with a Decreased Risk of HIV Disease Progression

• Published in: The Journal of infectious diseases Vol. 177; no. 2; pp. 331 - 336
• Main Authors: Ullum, Henrik, Lepri, Alessandro Cozzi, Victor, Jette, Aladdin, Hassan, Phillips, Andrew N., Gerstoft, Jan, Skinhøj, Peter, Pedersen, Bente Klarlund
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.02.1998; University of Chicago Press
• Subjects: AIDS; Biological and medical sciences; Blood; Chemokines; Disease progression; HIV; HIV infections; Human viral diseases; Infections; Infectious diseases; Linear regression; Lymphocytes; Major Articles; Medical sciences; Platelets; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Macrophage inflammatory protein 1β; Cytokine; Retroviridae; Biological marker; AIDS; Immune deficiency; Lentivirus; Blood; Infection; Virus; Chemokine; Viral disease; Risk factor; Evolution; Human immunodeficiency virus; Quantitative analysis
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/514192

Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES production were measured by ELISA in whole blood that had been stimulated for 4.5 h with phytohemagglutinin. The blood was from 90 healthy human immunodeficiency virus (HIV)-negative controls and from 245 HIVinfected subjects who were followed for ⩽4.5 years. HIV-infected persons without AIDS had increased levels of MIP-1α, MIP-1β, and RANTES (P < .01) compared with levels in controls. Subjects with AIDS, compared with controls, had decreased production levels of MIP-1β (P < .0001) and similar levels of MIP-1α and RANTES. A high level of MIP-1β production was associated with a decreased risk of progressing to AIDS or death, as determined by univariate analysis (P < .01) and adjusted for CD4 cell count and age (P = .07, P = .06, respectively). The findings suggest that the production level of β-chemokine changes during HIV infection and that a high level of β-chemokine production in peripheral blood lymphocytes may be associated with less rapid disease progression in HIV infection.