LSD acutely impairs working memory, executive functions, and cognitive flexibility, but not risk-based decision-making

• Published in: Psychological medicine Vol. 50; no. 13; pp. 2255 - 2264
• Main Authors: Pokorny, Thomas, Duerler, Patricia, Seifritz, Erich, Vollenweider, Franz X., Preller, Katrin H.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2020
• Subjects: Acute effects; Antagonists; Blindness; Candidates; Cognition & reasoning; Cognitive ability; Cognitive flexibility; Cognitive functioning; Cognitive impairment; Consciousness; Decision making; Drug use; Ecstasy; Executive function; Gambling; Hostility; Intelligence tests; Ketanserin; LSD; Lysergic acid diethylamide; Lysergide; Memory; Mental disorders; Mental task performance; Neuropsychological assessment; Original Articles; Pregnancy; Public health; Questionnaires; Risk taking; Schizophrenia; Serotonin receptors; Serotonin S2 receptors; Short term memory; Spatial memory; Switzerland; 5-HT2A receptor; cognition; executive functions; working memory; spatial memory; LSD; risk-based decision-making

Psychiatric and neurodegenerative illnesses are characterized by cognitive impairments, in particular deficits in working memory, decision-making, and executive functions including cognitive flexibility. However, the neuropharmacology of these cognitive functions is poorly understood. The serotonin...