Characterisation of the complement-regulatory proteins decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46) on a human colonic adenocarcinoma cell line

• Published in: Cancer Immunology, Immunotherapy Vol. 42; no. 3; pp. 185 - 192
• Main Authors: BJØRGE, L, JENSEN, T. S, MATRE, R
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.03.1996; Springer-Verlag
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Antigens, CD - metabolism; Antigens, CD - physiology; Biological and medical sciences; CD55 Antigens - metabolism; CD55 Antigens - physiology; Cell Division - physiology; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Medical sciences; Membrane Cofactor Protein; Membrane Glycoproteins - metabolism; Membrane Glycoproteins - physiology; Original; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumor Cells, Cultured; Tumors; Up-Regulation; Adenocarcinoma; Human; Immunohistochemistry; Host tumor relation; Serine endopeptidases; Enzyme; Pathogenesis; Cytotoxicity; Complement; Immune regulation; Malignant tumor; In vitro; Mechanism; Decay accelerating factor; Immunosuppression; Classical-complement-pathway C3/C5 convertase; Established cell line; Membrane cofactor protein; Digestive diseases; Hydrolases; Intestinal disease; Colon; Proteinases; Tumor cell

To avoid destruction by complement, normal and malignant cells express membrane glycoproteins that restrict complement activity. These include decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and protectin (CD59), which are all expressed on colonic adenocarcinoma cells in...